240931

Saccharin

≥99%

• Synonym(e): 2,3-Dihydro-1,2-benzisothiazol-3-on-1,1-dioxid, 2-Sulfobenzoesäureimid, o-Benzoesulfimid
• Empirische Formel (Hill-System): C₇H₅NO₃S
• CAS-Nummer: 81-07-2
• Molekulargewicht: 183.18
• Beilstein: 6888
• EG-Nummer: 201-321-0
• MDL-Nummer: MFCD00005866
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24854444
• NACRES: NA.22

Eigenschaften

• Assay: ≥99%
• Form: powder
• mp (Schmelzpunkt): 226-229 °C (lit.)
• Löslichkeit: acetone: 1g in 12mL(lit.); alcohol: 1g in 31mL(lit.); boiling water: 1g in 25mL(lit.); water: 1g in 25mL(lit.)
• SMILES String: O=C1NS(=O)(=O)c2ccccc12
• InChI: 1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
• InChIKey: CVHZOJJKTDOEJC-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

The biodegradation of saccharin (2-sulfobenzoic acid imide), an artificial sweetening agent, was studied. It was also studied for its carcinogenic potential.

Anwendung

• Gabapentin-saccharin co-crystals with enhanced physicochemical properties and in vivo absorption formulated as oro-dispersible tablets.: This study presents the formulation of gabapentin-saccharin co-crystals, demonstrating improved solubility and absorption, beneficial for pharmaceutical applications (Soliman et al., 2020, doi: 10.1080/10837450.2019.1687521).


• Improving the solubility, dissolution, and bioavailability of Ibrutinib by preparing it in a coamorphous state with saccharin.: The research focuses on enhancing the bioavailability of Ibrutinib through coamorphous preparation with saccharin, which is significant for cancer treatment (Shi et al., 2019, doi: 10.1016/j.xphs.2019.04.031).

Biochem./physiol. Wirkung

A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)