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ITGA2B

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

Synonyme:
BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(3674) Summary: ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
  • Mouse(16399) integrin alpha 2b
  • Rat(685269) integrin, alpha 2B
  • domestic guinea pig(100727374) integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
  • naked mole-rat(101714332) integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
  • Horse(100009697) integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
  • cow(515011) integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
  • sheep(101115719) integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
  • Zebrafish(445380) integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)
  • domestic cat(101100930) integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
  • dog(403789) integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

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Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
Gly-Arg-Gly-Asp-Ser-Pro-Lys, ≥97% (HPLC),
Spezies
human
Aspirin, meets USP testing specifications,
Spezies
human
Arg-Gly-Asp-Ser, ≥95% (HPLC),
Spezies
mouse, human
Acetylsalicylsäure, analytical standard,
Spezies
human
Acetylsalicylsäure, ≥99.0%,
Spezies
human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Integrin αIIb Mouse mAb (283.16B7), liquid, clone 283.16B7, Calbiochem®,
Speziesreaktivität
human
Anwendung
Anti-Platelet Antibody, clone PAC-1, clone PAC-1, from mouse,
Speziesreaktivität
human
Anwendung
ELISA
dot blot

flow cytometry

radioimmunoassay

western blot
Anti-Integrin α2b (CD41) antibody, Mouse monoclonal, clone PM6/248, purified from hybridoma cell culture,
Speziesreaktivität
baboon, human
Anwendung
flow cytometry
immunoprecipitation (IP)
Anti-CD41/ITGA2B antibody produced in rabbit, ,
Speziesreaktivität
human, mouse, rat
Anwendung
immunohistochemistry
western blot
Monoclonal Anti-CD41 antibody produced in rat, clone MWReg30,
Speziesreaktivität
mouse
Anwendung
flow cytometry

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
Tirofiban hydrochloride monohydrate, ≥98% (HPLC),
Spezies
human
Tirofiban, ≥98.5% (HPLC),
Spezies
human
Aspirin, meets USP testing specifications,
Spezies
human
Acetylsalicylsäure, analytical standard,
Spezies
human
Acetylsalicylsäure, ≥99.0%,
Spezies
human