F7053
Anti-vinculina monoclonal antibody produced in mouse
clone hVIN-1, purified from hybridoma cell culture
Sinónimos:
Monoclonal Anti-Vinculin antibody produced in mouse
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About This Item
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origen biológico
mouse
Nivel de calidad
conjugado
FITC conjugate
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
hVIN-1, monoclonal
Formulario
buffered aqueous solution
mol peso
antigen 116 kDa
reactividad de especies
frog, chicken, mouse, canine, human, bovine, rat, turkey
condiciones de almacenamiento
protect from light
técnicas
direct immunofluorescence: 1:50 using methanol/acetone fixed cultured bovine MDBK cells
isotipo
IgG1
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... VCL(7414)
mouse ... Vcl(22330)
rat ... Vcl(305679)
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Especificidad
Marca de manera específica la vinculina en los contactos célula-célula y célula-sustrato. Reacciona fuertemente con la vinculina humana. Muestra reactividad cruzada con la metavinculina del músculo liso.
Inmunógeno
vinculina humana purificada del útero.
Aplicación
Monoclonal Anti-Vinculin-FITC antibody is suitable for immunofluorescence staining of fibroblasts cells to study the effects of nanofiber spatial organization on cell behaviors. It is also suitable for direct immunofluorescence at a dilution of 1:50 using methanol/acetone fixed cultured bovine MDBK cells.
Acciones bioquímicas o fisiológicas
Vinculin is a cytoskeletal protein with molecular mass of ~116 kDa. Vinculin is closely associated with adhesive membrane areas, such as focal contacts, podosomes, or intercellular junctions of the zonula adherens type. It acts as a mediator in interactions of integrins and the actin cytoskeleton. It forms a bridge between integrins, receptors for ECM molecules on the cell surface and the F-actin cytoskeleton. It is associated with talin and α-actinin which directly connects with integrins. It has ability to bind α-catenin as well as the vasodilator stimulated phosphoprotein (VASP) in focal contact assembly.
Forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Descripción
Precios
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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