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227R-2

Sigma-Aldrich

BCL6 (EP278) Rabbit Monoclonal Primary Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

rabbit

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

EP278, monoclonal

descripción

(For In Vitro Diagnostic Use in Select Regions (See Chart))

Formulario

buffered aqueous solution

reactividad de especies

human

envase

bottle of 1.0 mL predilute (227R-27)
bottle of 7.0 mL predilute (227R-28)
vial of 0.1 mL concentrate (227R-24)
vial of 0.5 mL concentrate (227R-25)
vial of 1.0 mL concentrate (227R-26)
vial of 0.1 mL concentrate Research Use Only (227R-24-RUO)
vial of 1.0 mL concentrate Research Use Only (227R-26-RUO)
vial of 1.0 mL pre-dilute Research Use Only (227R-27-RUO)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (227R-28-RUO)

fabricante / nombre comercial

Cell Marque®

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotipo

IgG

control

tonsil

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

nuclear

Información sobre el gen

human ... BCL6(604)

Descripción general

BCL6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein.1 In normal tissue these antibodies have strong nuclear staining for a subset of B-lymphocytes, mostly located in germinal centers (GC).2 BCL6 antibodies stain malignant cells in follicular lymphoma,3 diffuse large B-cell lymphomas,4 Burkitt lymphoma,4 classical Hodgkin lymphoma,5 as well as majority of tumor cells in nodular lymphocyte predominant Hodgkin lymphoma.6 BCL6 expression has been also seen in anaplastic large cell lymphomas (ALCL).7

Calidad


IVD

IVD

IVD

RUO

Ligadura / enlace

BCL6 Positive Control Slides, Product No. 227S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Certificados de análisis (COA)

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Maria Bai et al.
Leukemia & lymphoma, 47(3), 495-501 (2006-01-07)
The bcl6/CD10/MUM1/CD138 B-cell differentiation immunophenotypes were analysed in 101 cases of classical Hodgkin lymphomas (cHL) aiming to elucidate their histogenesis. Three major bcl6/CD10/MUM1/CD138 immunophenotypes were distinguished on the basis of the immunohistochemical positivity of Hodgkin and Reed-Sternberg (H/RS) cells: (a)
Arzu Saglam et al.
Tumori, 97(5), 634-638 (2011-12-14)
Several transcription factors predominantly used for B-cell lineage identification are also expressed in a small percentage of T cells within germinal centers and interfollicular areas. The aim of the study was to evaluate the expression of Mum-1, Oct-2 and Bcl-6
Expression of BCL-6 protein and CD138/syndecan-1 as B-cell markers in Hodgkin's disease.
A Carbone et al.
The International journal of biological markers, 14(3), 144-148 (1999-11-24)
A Carbone et al.
Blood, 90(6), 2445-2450 (1997-10-06)
The expression pattern of the BCL-6 transcription factor has been assessed in normal and neoplastic B-cell populations and in Hodgkin's disease. However, little is known about BCL-6 expression and its biological significance in T-cell neoplasms. In this study, a series
A Carbone et al.
Blood, 91(3), 747-755 (1998-02-03)
This study was aimed at defining the histogenesis of the pathologic spectrum of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas (AIDS-NHL), including AIDS-related small noncleaved cell lymphoma (AIDS-SNCCL), AIDS-related large noncleaved cell lymphoma (AIDS-LNCCL), AIDS-related large cell immunoblastic lymphoma plasmacytoid (AIDS-IBLP), and

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