H1753

Hydralazine hydrochloride

synthetic (organic), ≥99% (TLC), DNA methyltransferase inhibitor, powder

• Synonym(s): 1-Hydrazinophthalazine hydrochloride
• Empirical Formula (Hill Notation): C₈H₈N₄ · HCl
• CAS Number: 304-20-1
• Molecular Weight: 196.64
• NACRES: NA.77
• PubChem Substance ID: 24278461
• UNSPSC Code: 12352200
• EC Number: 206-151-0
• MDL number: MFCD00135998
• Assay: ≥99% (TLC)
• Form: powder

Properties

• Product Name: Hydralazine hydrochloride,
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥99% (TLC)
• form: powder
• mp: 273 °C
• solubility: water: 50 mg/mL
• SMILES string: Cl[H].N\N=C1/N=NC=C2C=CC=CC12
• InChI: 1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;
• InChI key: SECXUXOCDLQOBI-MKFZHGHUSA-N
• Gene Information: human ... MAOA(4128), MAOB(4129)

Description

Application

Hydralazine hydrochloride has been used:

• as a vasodilator to study its effects on hypertension in T-cell frequencies in juvenile rats[1]
• as a semicarbazide-sensitive amine oxidase (SSAO) inhibitor to study its effects on myocardial ischemia-reperfusion (I/R) injury[2]
• as a vasodilator to study its effects on insulin secretion and glucose tolerance[3]

Biochem/physiol Actions

Hydralazine hydrochloride has therapeutic effects against heart failure and high blood pressure.

Inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression. Non-selective MAO-A/B inhibitor; antihypertensive; semicarbazide-sensitive amine oxidase inhibitor.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H315,H319,H335
• pcodes: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves