C8138

Chlorpromazine hydrochloride

≥98% (TLC), powder, D2 dopamine receptor antagonist

• Synonym(s): 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil
• Empirical Formula (Hill Notation): C₁₇H₁₉ClN₂S · HCl
• CAS Number: 69-09-0
• Molecular Weight: 355.33
• Beilstein/REAXYS Number: 3779989
• EC Number: 200-701-3
• MDL number: MFCD00012654
• UNSPSC Code: 12352200
• PubChem Substance ID: 57654045
• NACRES: NA.77

Properties

• product name: Chlorpromazine hydrochloride, ≥98% (TLC)
• assay: ≥98% (TLC)
• form: powder
• mp: 194-196 °C
• solubility: water: 50 mg/mL
• originator: GlaxoSmithKline
• SMILES string: Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13
• InChI: 1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
• InChI key: FBSMERQALIEGJT-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HRH1(3269) , HTR2A(3356)

Description

Application

Chlorpromazine hydrochloride has been used:

• as an antagonists for calmodulin kinase
• as a medium supplement to test its cytotoxic effects in human lung microvascular endothelial cells (HMVEC-L)
• as an inhibitor of clathrin-mediated endocytosis in RAW 264.7 cells

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Biochem/physiol Actions

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist, H₁ histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H330
• pcodes: P260 - P264 - P270 - P271 - P284 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges