Unless otherwise stated, this product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals.
61188
Losartan potassium
Synonym(s):
2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-methanol potassium salt, DuP 753, MK 954, Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 mg | Available to ship TODAYfromMILWAUKEE | $230.00 |
About This Item
Empirical Formula (Hill Notation):
C22H22ClKN6O
CAS Number:
Molecular Weight:
461.00
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5845770
$230.00
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form
powder or crystals
Quality Segment
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
impurities
≤0.5% water
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
SMILES string
CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
InChI
1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
InChI key
OXCMYAYHXIHQOA-UHFFFAOYSA-N
Gene Information
human ... AGTR1(185)
General description
Losartan potassium has long lasting effects, and its efficacy is generally increased, when combined with the diuretic co-active hydrochlorothiazide.
Losartan potassium is an antihypertensive drug that is found to be an angiotensin II receptor type 1 blocker. It finds applications in reducing mechanical stress thereby having a control over the condition of cardiac hypertrophy.
Application
Losartan potassium may be used as an analytical reference standard for the quantification of the analyte in the following:
- Pharmaceutical formulations using reversed-phase high-performance liquid chromatography and UV-spectrophotometric techniques.
- Rat plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.
orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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This Item | |||
|---|---|---|---|
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - | technique(s) - |
| application(s) forensics and toxicology | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical |
| form powder or crystals | form - | form - | form solid |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level - |
| shelf life limited shelf life, expiry date on the label | shelf life - | shelf life - | shelf life limited shelf life, expiry date on the label |
| impurities ≤0.5% water | impurities - | impurities - | impurities - |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 61188-100MG | 04061838443380 |
| 61188-100MG-9 | 04061838443397 |
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SIDE EFFECTS OF 90 LOSARTAN
1 answer-
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What HPLC column can I use for the analysis of Losartan in my samples?
1 answer-
Losartan is commonly analyzed using a C18 RP-HPLC column. Here at Supelco, we have successfully separated Valsartan, Losartan, and Irbesartan by HPLC chromatography on an Ascentis Express C18 15cm x 3mm column , using a mobile phase of 45:55, water:(0.1% formic acid in acetonitrile). Run times were less than 3 minutes, with the flow rate set at 0.4 mL/min (35° C).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What class of compound is Losartan Potassium, Product 61188?
1 answer-
Losartan is an angiotensin II receptor antagonist that is used to treat hypertension. It has imidazole, tetrazole, and benzene rings as part of its structure. It is anionic at neutral pH; it has a pKa in the range of 4-5.
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What do you suggest for sample preparation?
1 answer-
For extraction from biological fluids, consider HybridSPE - precipitation
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