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61188
Losartan potassium
Synonym(s):
2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-methanol potassium salt, DuP 753, MK 954, Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide
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100 MG
$215.00
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$219.00
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100 MG
$215.00
100 MG
$219.00
About This Item
Empirical Formula (Hill Notation):
C22H22ClKN6O
CAS Number:
Molecular Weight:
461.00
Beilstein/REAXYS Number:
5845770
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
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form
powder or crystals
Quality Level
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
impurities
≤0.5% water
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
SMILES string
CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
InChI
1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
Inchi Key
OXCMYAYHXIHQOA-UHFFFAOYSA-N
Gene Information
human ... AGTR1(185)
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General description
Losartan potassium has long lasting effects, and its efficacy is generally increased, when combined with the diuretic co-active hydrochlorothiazide.[1]
Losartan potassium is an antihypertensive drug that is found to be an angiotensin II receptor type 1 blocker. It finds applications in reducing mechanical stress thereby having a control over the condition of cardiac hypertrophy.[2]
Application
Losartan potassium may be used as an analytical reference standard for the quantification of the analyte in the following:
- Pharmaceutical formulations using reversed-phase high-performance liquid chromatography[3][4][5] and UV-spectrophotometric techniques.[4]
- Rat plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique.[6]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.
orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Customers Also Viewed
Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography
Carlucci G, et al.
Journal of Pharmaceutical and Biomedical Analysis, 23(1), 185-189 (2000)
Christopher J Haddock et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 318(6), R1027-R1035 (2020-04-16)
There are examples of physiological conditions under which thirst is inappropriately exaggerated, and the mechanisms for these paradoxical ingestive behaviors remain unknown. We are interested in thirst mechanisms across the female life cycle and have identified a novel mechanism through
Michael D Kim et al.
ERJ open research, 7(1) (2021-02-04)
The aim was to determine whether losartan reduces cigarette smoke (CS)-induced airway inflammation and mucus hypersecretion in an in vitro model and a small clinical trial. Primary human bronchial epithelial cells (HBECs) were differentiated at the air-liquid interface (ALI) and
LC/MS/MS method for the simultaneous estimation of losartan potassium and irbesartan in rat plasma
Prasad BGSVS, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 1(The), 206-215 (2009)
Mechanical stress-evoked but angiotensin II-independent activation of angiotensin II type 1 receptor induces cardiac hypertrophy through calcineurin pathway
Zhou N, et al
Biochemical and Biophysical Research Communications, 397, 263-269 (2010)
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What is the Department of Transportation shipping information for this product?
1 answer-
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What do you suggest for sample preparation?
1 answer-
For extraction from biological fluids, consider HybridSPE - precipitation
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What HPLC column can I use for the analysis of Losartan in my samples?
1 answer-
Losartan is commonly analyzed using a C18 RP-HPLC column. Here at Supelco, we have successfully separated Valsartan, Losartan, and Irbesartan by HPLC chromatography on an Ascentis Express C18 15cm x 3mm column , using a mobile phase of 45:55, water:(0.1% formic acid in acetonitrile). Run times were less than 3 minutes, with the flow rate set at 0.4 mL/min (35° C).
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What class of compound is Losartan Potassium, Product 61188?
1 answer-
Losartan is an angiotensin II receptor antagonist that is used to treat hypertension. It has imidazole, tetrazole, and benzene rings as part of its structure. It is anionic at neutral pH; it has a pKa in the range of 4-5.
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