C6506

4-Chloro-DL-phenylalanine

• Synonyme(s) : PCP, PCPA
• Formule linéaire : ClC₆H₄CH₂CH(NH₂)CO₂H
• Numéro CAS: 7424-00-2
• Poids moléculaire : 199.63
• Numéro CE : 231-051-9
• Numéro MDL: MFCD00002601
• Code UNSPSC : 12352209
• ID de substance PubChem : 24278081
• Nomenclature NACRES : NA.32

Propriétés

• Forme: solid
• Niveau de qualité: 100
• Score du produit alternatif plus écologique: old score: 2; new score: 1; Find out more about DOZN™ Scoring
• Caractéristiques du produit alternatif plus écologique: Less Hazardous Chemical Syntheses; Designing Safer Chemicals; Design for Energy Efficiency; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• Pf: >240 °C (dec.) (lit.)
• Autre catégorie plus écologique: , Re-engineered
• Température de stockage: room temp
• Chaîne SMILES: NC(Cc1ccc(Cl)cc1)C(O)=O
• InChI: 1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
• Clé InChI: NIGWMJHCCYYCSF-UHFFFAOYSA-N
• Informations sur le gène: human ... TPH1(7166) , TPH2(121278)

Description

Description générale

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.

Application

4-Chloro-DL-phenylalanine has been used:

• as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras⁺ male zebrafish
• to induce insomnia in rat models
• used to treat embryos to examine its effect on serotonin
• for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
• to feed flies to explore serotonin effect

Actions biochimiques/physiologiques

4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.

Tryptophan hydroxylase inhibitor.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301,H317
• Conseils de prudence: P280 - P301 + P310 + P330 - P302 + P352
• Classification des risques: Acute Tox. 3 Oral - Skin Sens. 1
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges