M3071

Moclobemide

≥98% (HPLC), MAOI inhibitor, solid

• Synonyme(s) : 4-chloro-N-[2-(4-morpholinyl)ethyl]benzamide, Aurorix, Moclamine
• Formule empirique (notation de Hill) : C₁₃H₁₇ClN₂O₂
• Numéro CAS: 71320-77-9
• Poids moléculaire : 268.74
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817960
• NACRES: NA.77
• MDL number: MFCD00865388
• Assay: ≥98% (HPLC)
• Form: solid

Propriétés

• Nom du produit: Moclobemide, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: >20 mg/mL
• originator: Roche
• storage temp.: room temp
• SMILES string: Clc1ccc(cc1)C(=O)NCCN2CCOCC2
• InChI: 1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)
• InChI key: YHXISWVBGDMDLQ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Moclobemide acts as a substrate for cytochrome P450 2C19 (CYP2C19). It also behaves as an inhibitor of cytochrome P450 2D6 (CYP2D6), cytochrome P450 1A2 (CYP1A2 and CYP2C19. Moclobemide is also involved in the increased expression of B-cell lymphoma 2 (BcL-2). It also causes neural stem cell (NSC) differentiation into serotoninergic neuron by extracellular‐regulated kinase (ERK) pathway.

Moclobemide is a reversible monoamine oxidase A inhibitor (MAOI); antidepressant.

Moclobemide is a reversible monoamine oxidase A inhibitor (MAOI); antidepressant. Elimination half-life in humans = 1 -3 hrs; absolute oral bioavailability. Unlike other MAO inhibitors, does not significantly increase blood pressure in humans upon combination with tyramine.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07
• Mot-clé: Danger
• Codes de danger: H302,H315,H318,H335
• Mentions de précaution: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): dust mask type N95 (US), Eyeshields, Gloves