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Muscimol hydrobromide

Name: Muscimol hydrobromide
Brand: SIGMA

≥98% (HPLC), GABAA receptor agonist, solid

Synonym(s):

5-Aminomethyl-3-hydroxyisoxazole hydrobromide

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About This Item

Empirical Formula (Hill Notation):

C₄H₆N₂O₂ · HBr

CAS Number:

18174-72-6

Molecular Weight:

195.01

UNSPSC Code:

12352200

PubChem Substance ID:

24278168

NACRES:

NA.77

MDL number:

MFCD00055184

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Product Name

Muscimol hydrobromide, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white to tan

solubility

H₂O: >10 mg/mL

storage temp.

2-8°C

SMILES string

Br[H].NCc1cc(O)no1

InChI

1S/C4H6N2O2.BrH/c5-2-3-1-4(7)6-8-3;/h1H,2,5H2,(H,6,7);1H

InChI key

OPZOJWHOZRKYQX-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Description

Biochem/physiol Actions

Muscimol hydrobromide is a GABA_A receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	P0618	A9111	S143
Sigma-Aldrich G019 Muscimol hydrobromide	Sigma-Aldrich P0618 cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole hydrobromide	Sigma-Aldrich A9111 (±)-AMPA hydrobromide	Sigma-Aldrich S143 (±)-6-Chloro-PB hydrobromide
form solid	form solid	form powder	form solid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -
solubility H₂O: >10 mg/mL	solubility H₂O: soluble ~10 mg/mL at 60 °C (Sonicate), DMSO: soluble 12 mg/mL	solubility H₂O: ≥10 mg/mL	solubility H₂O: 1.7 mg/mL, DMSO: >10 mg/mL, ethanol: 6.3 mg/mL
color off-white to tan	color light brown	color off-white to light tan	color white to light tan

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Brief cortical deactivation early in life has long-lasting effects on multisensory behavior.

Benjamin A Rowland et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7198-7202 (2014-05-23)

Detecting and locating environmental events are markedly enhanced by the midbrain's ability to integrate visual and auditory cues. Its capacity for multisensory integration develops in cats 1-4 months after birth but only after acquiring extensive visual-auditory experience. However, briefly deactivating

Compensating Level-Dependent Frequency Representation in Auditory Cortex by Synaptic Integration of Corticocortical Input.

Max F K Happel et al.

PloS one, 12(1), e0169461-e0169461 (2017-01-04)

Robust perception of auditory objects over a large range of sound intensities is a fundamental feature of the auditory system. However, firing characteristics of single neurons across the entire auditory system, like the frequency tuning, can change significantly with stimulus

Vibrissa-based object localization in head-fixed mice.

Daniel H O'Connor et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(5), 1947-1967 (2010-02-05)

Linking activity in specific cell types with perception, cognition, and action, requires quantitative behavioral experiments in genetic model systems such as the mouse. In head-fixed primates, the combination of precise stimulus control, monitoring of motor output, and physiological recordings over

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Global Trade Item Number

SKU	GTIN
G019-5MG	04061833623367
G019-100MG	04061832082127
G019-10MG	04061832082134
G019-25MG	04061833623350

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