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Merck

Therapeutic Antibody Development

Tools to accelerate preclinical studies in antibody
drug development.

HomeIntegrated OfferingsMonoclonal Antibodies (mAbs)Antibody Drug DiscoveryTherapeutic Antibody Preclinical Development

 

Robust preclinical methods are crucial for evaluation of potential antibody drugs, ensuring that time, money, and effort are spent on the most promising candidates with greatest therapeutic potential. Recent advances in preclinical modeling and multi-parameter analysis have significantly improved the rigor of experimental evaluation of lead antibody candidates. Our products provide more biologically relevant models and enable more comprehensive assessment to accelerate therapeutic antibody development. 

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Therapeutic Antibody Preclinical Development

Therapeutic Antibody Preclinical Development

Fail Faster With Predictive Preclinical Studies

The high failure rate of drug candidates due to safety and efficacy concerns necessitates the use of preclinical in vitro and in vivo models to help predict the safety and clinical efficacy of lead drug candidates during early-stage drug development. We offer a wide range of tools to support in vitro and in vivo testing, pharmacokinetic analysis, pharmacology assessment, and toxicology studies, enabling our clients to more comprehensively evaluate antibody drug candidates. 

Models for preclinical assessment of monoclonal antibodies, including 2D cell culture, 3D cell culture, organoids, animal models, and studies using human samples.

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Cell Lines & Specialty Cell Culture

ECACC cultures, primary cells, assay-ready cells, and bioprocessing cell lines.

Protein mass spectrometry tools
Organoids

Human iPSC-derived and patient-derived organoids for advanced cell culture.

Close-up photograph of fetal bovine serum being pipetted into a cell culture media bottle
Cell Culture Supplements & Reagents

High quality sera, growth factors, amino acids, vitamins, and more for cell culture.

A mass spectrometer sits in focus in the center of the photo. Behind and to the right stands a scientist with his back turned
Protein Mass Spectrometry

Comprehensive mass spectrometry reagents to cover your complete workflow.

MILLIPEX® Multiplexing Immunoassay reagents next to a Luminex® instrument
MILLIPLEX® Multiplex for Luminex® Immunoassays

Analyze preclinical response with MILLIPLEX® multiplexing biomarker assays.

SMC (Single Molecule Counting) Assay Kit
SMC® Ultrasensitive Immunoassay Technology

SMC® high sensitivity technology for sensitivity down to the single molecule.


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