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SML3078

Sigma-Aldrich

JT003 trifluoroacetate

≥95% (HPLC)

Synonym(s):

P-Nva-LYYFA trifluoroacetate

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5 MG
$147.00

$147.00

Estimated to ship onApril 17, 2025

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5 MG
$147.00

About This Item

Empirical Formula (Hill Notation):
C46H62N8O9 · xC2HF3O2
Molecular Weight:
871.03 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.77

$147.00

Estimated to ship onApril 17, 2025

Request a Bulk Order

Quality Level

100

assay

≥95% (HPLC)

form

film or powder

color

white to off-white

storage temp.

−20°C

Biochem/physiol Actions

JT003 is potent dual agonist of adiponectin receptors AdipoR1/AdipoR2 that potently improves insulin resistance in high fat diet induced nonalcoholic steatohepatitis (NASH) mice. JT003 inhibits hepatic stellate cells (HSCs) activation in CCl4 induced liver fibrosis.
potent dual agonist of adiponectin receptors AdipoR1/AdipoR2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Hongjiao Xu et al.
Nature communications, 11(1), 5807-5807 (2020-11-18)
Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors AdipoR1 and AdipoR2, and AdipoRs
Michishige Terasaki et al.
International journal of molecular sciences, 21(13) (2020-07-11)
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to play a protective role against atherosclerosis in both animal models and patients with type 2 diabetes (T2D). However, since T2D is associated with dyslipidemia, hypertension and insulin resistance, part of which are

Questions

  1. Good afternoon, I would like to know the solubility of compound JT003 for in vivo experiments on mice.  Thank you. Maria

    1 answer

    1. This product is not tested for in vivo or in vitro use. Several publication indicate that this compound has been used successfully in mouse models. Please see the links below to review publications that may be of interest.
      https://pubmed.ncbi.nlm.nih.gov/36873175/
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669869/

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