F7932

Famciclovir

≥98% (HPLC)

• Synonym(s): 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester, BRL 42810
• Empirical Formula (Hill Notation): C₁₄H₁₉N₅O₄
• CAS Number: 104227-87-4
• Molecular Weight: 321.33
• NACRES: NA.77
• PubChem Substance ID: 329799767
• UNSPSC Code: 12352200
• MDL number: MFCD00866964
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• solubility: DMSO: ≥10 mg/mL
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(C)=O
• InChI: 1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
• InChI key: GGXKWVWZWMLJEH-UHFFFAOYSA-N

Description

Application

Famciclovir is used in herpes virus infections and hepatitis B drug development research. It may be used as a reference compound. Famciclovir may be used to study the factors that control its conversion into penciclovir and other metabolites.[1][2]

Biochem/physiol Actions

Famciclovir is an Antiviral; Guanine analog used to treat herpesvirus infections.

Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable