D033

(+)-Butaclamol hydrochloride

• Empirical Formula (Hill Notation): C₂₅H₃₁NO · HCl
• CAS Number: 55528-07-9
• Molecular Weight: 397.98
• NACRES: NA.77
• PubChem Substance ID: 24278400
• UNSPSC Code: 12352200
• MDL number: MFCD00082307

Properties

• form: powder
• Quality Level: 100
• optical activity: [α]27/D +222° in methanol(lit.)
• storage condition: desiccated
• color: white
• solubility: DMSO: >10 mg/mL, clear
• SMILES string: Cl[H].[H][C@@]12C[C@@](O)(CCN1C[C@@]3([H])c4ccccc4CCc5cccc2c35)C(C)(C)C
• InChI: 1S/C25H31NO.ClH/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25;/h4-10,21-22,27H,11-16H2,1-3H3;1H/t21-,22-,25-;/m0./s1
• InChI key: QZRUMKUMFJJARD-AAJWHBHYSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Description

Application

(+)-Butaclamol hydrochloride has been used as a dopamine receptor blocker in:

• dissected brain sections[1]
• striatum of Parkinson′s disease specimens[2]
• human embryonic kidney cells (HEK293 cells)[3]
• mice striatal tissue[4]

Biochem/physiol Actions

(+)-Butaclamol is a dopamine receptor antagonist and is an active enantiomer.[5]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)