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Sigma-Aldrich

Dextran sulfate sodium salt

Mr ~40,000

Synonym(s):

DSS Dextran Sulfate Sodium

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About This Item

UNSPSC Code:
12352201
NACRES:
NA.25

form

powder

mol wt

Mr ~40,000

loss

≤10% loss on drying

color

white to off-white

useful pH range

6.0-8 (10 g/L)

mp

(Decomposes on heating.)

solubility

water: soluble

storage temp.

room temp

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General description

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.

Application

Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.

Biochem/physiol Actions

Treatment with dextran sulfate sodium triggers development of colitis in mice and rats by binding to medium-chain-length fatty acids present in the colon and inducing inflammation.

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Li Cao et al.
International immunopharmacology, 72, 264-274 (2019-04-21)
Extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs) have shown repairing effects in tissue damage. However, their efficacy and mechanism in the treatment of ulcerative colitis (UC), a type of chronic inflammatory bowel disease, are unclear. To
Hamed Laroui et al.
PloS one, 7(3), e32084-e32084 (2012-03-20)
Inflammatory bowel diseases (IBDs), primarily ulcerative colitis and Crohn's disease, are inflammatory disorders caused by multiple factors. Research on IBD has often used the dextran sodium sulfate (DSS)-induced colitis mouse model. DSS induces in vivo but not in vitro intestinal
Andrey V Markov et al.
Molecules (Basel, Switzerland), 25(10) (2020-05-28)
Semi-synthetic triterpenoids, bearing cyano enone functionality in ring A, are considered to be novel promising therapeutic agents with complex inhibitory effects on tissue damage, inflammation and tumor growth. Previously, we showed that the cyano enone-containing 18βH-glycyrrhetinic acid derivative soloxolone methyl
Yueqin He et al.
Scientific reports, 10(1), 10180-10180 (2020-06-25)
CD47 deficient mice are resistant to dextran sulfate sodium (DSS)-induced experimental colitis. The underlying mechanism, however, remains incompletely understood. In this study, we characterized the role of CD47 in modulating homeostasis of gastrointestinal tract. We found that CD47 expression in
Maike M K Hansen et al.
Cell, 173(7), 1609-1621 (2018-05-15)
Diverse biological systems utilize fluctuations ("noise") in gene expression to drive lineage-commitment decisions. However, once a commitment is made, noise becomes detrimental to reliable function, and the mechanisms enabling post-commitment noise suppression are unclear. Here, we find that architectural constraints
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