The recommended guard column for the 15024AST column is 15100AST, which is an Astec® CHIROBIOTIC® V2 Chiral HPLC Guard Column Cartridge with a 5 μm particle size and dimensions of 2 cm length and 4 mm inner diameter. Additionally, the recommended holder is 21150AST, a Supelguard™ Guard Cartridge Holder Stand-Alone (Swivel-type) designed for use with Supelguard cartridges, with dimensions of 2 cm length and 2 to 4.6 mm inner diameter.
推薦產品
產品名稱
Astec® CHIROBIOTIC® V2手性HPLC色谱柱, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
材料
stainless steel column
品質等級
agency
suitable for USP L88
描述
HPLC column
產品線
Astec®
包裝
pkg of 1 ea
製造商／商標名
Astec®
參數
0-45 °C temperature
241 bar pressure (3500 psi)
技術
HPLC: suitable
LC/MS: suitable
長度 × 內徑
25 cm × 4.6 mm
基質
High-purity silica gel particle platform
fully porous particle
基質活性組
vancomycin phase
粒徑
5 μm
孔徑
200 Å
工作pH值範圍
3.5-7.0
分離技術
chiral
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一般說明
中性分子、酰胺、酸、酯和胺对这些基于万古霉素的CSP显示出相当大的对映选择性。在CHIROBIOTIC® V的极性离子模式下，分离出各种各样的仲胺和叔胺分子。CHIROBIOTIC® V已经表现出蛋白质固定相的许多分离特性，但同时具有出色的稳定性和更高的样品容量。一些尚未报道在任何其他手性固定相上得到分离的手性分析物被分离出来。CHIROBIOTIC® V和V2的区别在于键合化学性质与载体颗粒的孔径不同，这赋予它们不同的选择性和制备能力。
CHIROBIOTIC FAQ
CHIROBIOTIC参考书目
Chiral产品文献
- 键合相：万古霉素
- 工作pH范围：3.5 - 7.0
- 粒径：5、10或16 μm
- 孔径：100Å（CHIROBIOTIC® V）或200Å（CHIROBIOTIC® V2）
CHIROBIOTIC FAQ
CHIROBIOTIC参考书目
Chiral产品文献
應用
- Chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography-tandem mass spectrometry： 采用CHIROBIOTIC® V2色谱柱手性分离人体毛发中的右美沙芬和左美沙芬，说明柱子可在法医毒理学中用于准确的手性拆分(Ji et al., 2022)。
- Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma： 在大鼠药动学研究中采用CHIROBIOTIC® V2色谱柱建立对映选择性测定方法，对药物开发和治疗监测有重要意义(Zhang et al., 2016)。
- New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase： 用CHIROBIOTIC® V2色谱柱开发新的HPLC方法分离华法林对映体，说明它的临床分析和治疗药物监测用处，体现生物医学研究应用的广泛性(Malakova et al., 2009)。
法律資訊
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
應用
產品號碼
描述
訂價
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相關內容
Astec CHIROBIOTIC™ V2 Chiral HPLC Columns offered by Sigma-Aldrich. The polar organic and the polar ionic modes have become increasingly popular largely because of their ideal compatibility with MS detection and preparative LC.
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