T9823

四环素 盐酸盐

Biotechnology Performance Certified, suitable for cell culture, ≥95%

• 經驗公式（希爾表示法）: C₂₂H₂₄N₂O₈ · HCl
• CAS號碼: 64-75-5
• 分子量：: 480.90
• Beilstein: 3844873
• EC號碼: 200-593-8
• MDL號碼: MFCD00078142
• 分類程式碼代碼: 51101500
• PubChem物質ID: 24900607

屬性

• 等級: Biotechnology Performance Certified
• 化驗: ≥95%
• 技術: cell culture | mammalian: suitable
• 雜質: endotoxin, tested
• mp: 220-223 °C (lit.)
• 溶解度: H₂O: soluble 50 mg/mL
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 作用方式: protein synthesis | interferes
• 儲存溫度: −20°C
• SMILES 字串: Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
• InChI 密鑰: XMEVHPAGJVLHIG-FMZCEJRJSA-N

描述

一般說明

Chemical structure: tetracycline

應用

Tetracycline is a broad spectrum polyketide antibiotic. It is used clinically to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever and Brill-Zinsser disease. It is used to treat upper respiratory infections and acne. It is used to study multidrug resistance as well as potential side effects such as acute pancreatitis. It has been used in target and resistance based mechanistic studies of novel antibiotics.

生化／生理作用

作用机制：四环素通过细胞膜中的 proin 通道被动扩散，与 30S 核糖体结合，并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合，改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用，这表明起到抗菌作用的是可逆结合的抗生素，而不是不可逆结合的药物。

耐药性机制：这种作用通过细胞壁通透性的丧失而失活。

抗菌谱：包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。

Tetracycline inhibits bacterial protein synthesis elongation at the level of aminoacyl-tRNA binding to the 30S ribosome. Tetracycline passively diffuses through porin channels in the bacterial cell membrane. It also binds to the bacterial 50S ribosomal subunit which may alter the cytoplasmic membrane, causing intracellular components to leak from bacterial cells. Mode of resistance is loss of cell wall permeability.

安全資訊

• 象形圖: GHS08,GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H315,H319,H335,H361fd,H410
• 防範說明: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• 危險分類: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves