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Merck
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重要文件

87128

Sigma-Aldrich

四环素

98.0-102.0% (HPLC)

同義詞:

Tetracycline HCL, Tetracycline Monohydrochloride

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About This Item

經驗公式(希爾表示法):
C22H24N2O8 · xH2O
CAS號碼:
分子量::
444.43 (anhydrous basis)
Beilstein:
2230417
EC號碼:
MDL號碼:
分類程式碼代碼:
51284017
PubChem物質ID:
NACRES:
NA.85
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生物源

synthetic

品質等級

化驗

98.0-102.0% (HPLC)

形狀

powder or crystals

顏色

faint yellow to dark yellow

mp

172-174 °C (dec.)

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

InChI 密鑰

OFVLGDICTFRJMM-WESIUVDSSA-N

基因資訊

尋找類似的產品? 前往 產品比較指南

一般說明

化学结构:四环素

生化/生理作用

作用机制:四环素通过细胞膜中的 proin 通道被动扩散,与 30S 核糖体结合,并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合,改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用,这表明起到抗菌作用的是可逆结合的抗生素,而不是不可逆结合的药物。

耐药性机制:这种作用通过细胞壁通透性的丧失而失活。

抗菌谱:包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。

包裝

25g, 100g

其他說明

保存于密闭容器内,置于干燥通风处。吸湿。光敏感。置于干燥处保存。

相關產品

產品號碼
描述
訂價

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Questions

1–2 of 2 Questions  
  1. How to prepare stock solutions for item 87128-25G, Tetracycline?

    1 answer
    1. Tetracycline is soluble in methanol, giving a clear solution at up to 30 mg/ml. It is practically insoluble in chloroform and ether, very slightly soluble in water, slightly soluble in alcohol, very soluble in dilute hydrochloric acid and alkali hydroxide solutions.

      Helpful?

  2. devo fare lo stock della tetraciclina. come e in cosa la devo diluire?

    1 answer
    1. This product is soluble in methanol or ethanol, giving a completely clear solution at up to 30 mg/ml. The stability of this material in solution is pH-dependent. Stock solutions prepared in ethanol are estimated to be stable for 1-3 months when aliquoted and stored at -20°C. Please see the link below to review the product datasheet for T3258, an identical tetracycline product of another brand. The information provided applies to both products.
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/406/734/t3258dat.pdf

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