推薦產品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 80-100 kDa
物種活性
human
加強驗證
recombinant expression
Learn more about Antibody Enhanced Validation
濃度
~1 mg/mL
技術
immunoprecipitation (IP): 10-20 μg using TGN46 from human HepG2 cell lysates.
indirect immunofluorescence: 5-10 μg/mL using human A549 cells
western blot (chemiluminescent): 0.25-0.5 μg/mL using extracts of human HEK-293T cells expressing recombinant human TGN46
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TGOLN2(10618)
一般說明
TGN46（反式高尔基体网络蛋白，46 kDa）是大鼠TGN38的人类同源物，是反式高尔基体网络（TGN）的固有整合膜蛋白，其可在TGN和质膜之间进行组成性循环，并通过内体返回。TGN是蛋白质分泌途径、脂质和膜运输的的主要分选细胞器。TGN46是一种高度糖基化的蛋白质，可能参与调节往返TGN的膜运输。TGN46包含信号肽、内腔结构域、跨膜结构域和胞质结构域。跨膜区域和胞质尾巴分别包含保留和回收信号，可用于TGN的定位。TGN46在细胞中广泛表达。
抗TGN46可识别人反式高尔基体网络蛋白2（TGN46）。通过免疫印迹对TGN46条带的检测可被免疫肽特异性抑制。
免疫原
对应于人TGN46的氨基酸残基426-437的合成肽，N-末端添加有半胱氨酸，并与KLH偶联。与大鼠中的相应序列相同，与人的相应序列相差2个氨基酸。
應用
兔多克隆抗TGN46抗体可用于标记反式高尔基体网络蛋白2，并可通过免疫细胞化学和免疫组化（IHC）技术（例如免疫印迹、免疫沉淀和免疫荧光）进行检测和定量。它可作为探针，对反式高尔基网络蛋白2[作为反式高尔基网络（TGN）的膜转运调节成分]的存在和作用进行确定。抗TGN46可用作TGN标记。
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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分析證明 (COA)
Lot/Batch Number
Yong Yu et al.
The Biochemical journal, 434(3), 383-390 (2011-01-22)
Peptide hormones and neuropeptides are packaged and stored in a specialized intracellular organelle called the dense core vesicle. It remains elusive how peptide cargoes are correctly sorted. In the present study, we show that a highly conserved Golgi-localized protein named
Jiehua Li et al.
Autophagy, 13(2), 345-358 (2016-11-23)
The membrane source for autophagosome biogenesis is an unsolved mystery in the study of autophagy. ATG16L1 forms a complex with ATG12-ATG5 (the ATG16L1 complex). The ATG16L1 complex is recruited to autophagic membranes to convert MAP1LC3B-I to MAP1LC3B-II. The ATG16L1 complex
Andrea N Dietz et al.
Journal of virology, 92(1) (2017-10-20)
The human cytomegalovirus (HCMV) tegument protein pUL71 is required for efficient secondary envelopment and accumulates at the Golgi compartment-derived viral assembly complex (vAC) during infection. Analysis of various C-terminally truncated pUL71 proteins fused to enhanced green fluorescent protein (eGFP) identified
Wolfgang M Schmidt et al.
American journal of human genetics, 97(6), 855-861 (2015-11-20)
Hereditary ataxias comprise a group of genetically heterogeneous disorders characterized by clinically variable cerebellar dysfunction and accompanied by involvement of other organ systems. The molecular underpinnings for many of these diseases are widely unknown. Previously, we discovered the disruption of
Christine M Calton et al.
PLoS pathogens, 13(5), e1006200-e1006200 (2017-05-04)
The human papillomavirus type 16 (HPV16) L2 protein acts as a chaperone to ensure that the viral genome (vDNA) traffics from endosomes to the trans-Golgi network (TGN) and eventually the nucleus, where HPV replication occurs. En route to the nucleus
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