Endoplasmic reticulum-Golgi intermediate compartment 53kDa protein (ERGIC-53), a nonglycosylated, hexameric type I integral membrane protein is also known as LMAN1 (lectin, mannose-binding 1). This gene is located on human chromosome 18q21.32.
免疫原
synthetic peptide corresponding to an internal sequence of human ERGIC-53, conjugated to KLH. The corresponding sequence is identical in mouse, rat, bovine and monkey.
生化／生理作用
Endoplasmic reticulum-Golgi intermediate compartment protein 53kDa protein (ERGIC-53) plays an important role in the proliferation of arenavirus, coronavirus and filovirus. This intracellular cargo receptor enables the anterograde passage of very few glycoprotein ligands in the early exocytic pathway. Mutations in ERGIC-53 (LMAN1) gene results in the deficiency of factor V and factor VIII.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Two new mutations at ERGIC-53 gene in a Turkish family
Torun, et al.
Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 17(3), 248-250 (2011)
Dependence on electron transport chain function and intracellular signaling of genomic responses in SH-SY5Y cells to the mitochondrial neurotoxin MPP+
The Journal of cell biology, 194(1), 61-75 (2011-07-06)
Glycosylphosphatidylinositol (GPI) anchoring of proteins is a posttranslational modification occurring in the endoplasmic reticulum (ER). After GPI attachment, proteins are transported by coat protein complex II (COPII)-coated vesicles from the ER. Because GPI-anchored proteins (GPI-APs) are localized in the lumen
The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles
Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm1. Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein STING, which then activates the kinases IKK
