T7154

Tyr-Ile-Gly-Ser-Arg

≥97% (HPLC)

• 同義詞: Laminin Fragment 929-933
• 經驗公式（希爾表示法）: C₂₆H₄₂N₈O₈
• CAS號碼: 110590-64-2
• 分子量：: 594.66
• MDL號碼: MFCD00076472
• 分類程式碼代碼: 12352209
• PubChem物質ID: 24900419
• NACRES: NA.32

屬性

• 生物源: synthetic (organic)
• 品質等級: 200
• 化驗: ≥97% (HPLC)
• 形狀: powder
• 技術: cell culture | mammalian: suitable
• 溶解度: H₂O: soluble 1 mg/mL, clear, colorless
• 儲存溫度: −20°C
• SMILES 字串: CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H,3-5,10-13,27H2,1-2H3,(H,31,40)(H,32,37)(H,33,39)(H,34,38)(H,41,42)(H4,28,29,30)/t14-,17-,18-,19-,21-/m0/s1
• InChI 密鑰: MWOGMBZGFFZBMK-LJZWMIMPSA-N

描述

Amino Acid Sequence

Tyr-Ile-Gly-Ser-Arg

應用

Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins β1, α6, and α3 in promoting type II epithelial differentiation during lung maturation in the fetus.

生化／生理作用

Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro. It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells.

Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis.

準備報告

Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)