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重要文件

T4626

Sigma-Aldrich

Nα-p甲苯磺酰基-L-精氨酸甲酯 盐酸盐

≥98% (TLC), suitable for ligand binding assays

同義詞:

TAME 盐酸盐

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About This Item

線性公式:
H2NC(=NH)NH(CH2)3CH(NHSO2C6H4CH3)CO2CH3 · HCl
CAS號碼:
分子量::
378.87
Beilstein:
3922357
EC號碼:
MDL號碼:
分類程式碼代碼:
12352103
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.26
暫時無法取得訂價和供貨情況

產品名稱

Nα-p甲苯磺酰基-L-精氨酸甲酯 盐酸盐,

化驗

≥98% (TLC)

形狀

powder

技術

ligand binding assay: suitable

顏色

white

mp

145-147 (lit.)

儲存溫度

−20°C

SMILES 字串

Cl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1

InChI

1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1

InChI 密鑰

JIQFFACVQXXHMY-YDALLXLXSA-N

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應用

Nα-甲苯磺酰基-L-精氨酸甲酯盐酸盐已被用作酯水解底物,用于评估中肠提取物中胰蛋白酶样活性。[1]它也已被用作测定胰酶[2]和人肠样品中胰蛋白酶活性的底物。[3]

生化/生理作用

Nα-对甲苯磺酰基-L-精氨酸甲酯(TAME)与后期促进复合物(APC)结合并阻止其被Cdc20和Cdh1激活。

基底

胰蛋白酶、[4]凝血酶、[4]纤溶酶[5]和其他蛋白酶的底物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

Sappasith Klomklao et al.
Journal of agricultural and food chemistry, 54(15), 5617-5622 (2006-07-20)
Trypsin from tongol tuna (Thunnus tonggol) spleen was purified to 402-fold by ammonium sulfate precipitation, followed by a series of chromatographic separations. The molecular mass of trypsin was estimated to be 24 kDa by size-exclusion chromatography and sodium dodecyl sulfate-polyacrylamide
Character of a wheat amylase inhibitor preparation and effects on fasting human pancreaticobiliary secretions and hormones
Choudhury A, et al.
Gastroenterology, 111(5), 1313-1320 (1996)
Xing Zeng et al.
Cancer cell, 18(4), 382-395 (2010-10-19)
Microtubule inhibitors are important cancer drugs that induce mitotic arrest by activating the spindle assembly checkpoint (SAC), which, in turn, inhibits the ubiquitin ligase activity of the anaphase-promoting complex (APC). Here, we report a small molecule, tosyl-L-arginine methyl ester (TAME)
In vitro digestibility of goat milk and kefir with a new standardised static digestion method (INFOGEST cost action) and bioactivities of the resultant peptides
El SN, et al.
Food & Function, 6(7), 2322-2330 (2015)
A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.
B C HUMMEL
Canadian journal of biochemistry and physiology, 37, 1393-1399 (1959-12-01)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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