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T3397

Sigma-Aldrich

泰乐菌素 溶液

solution, suitable for cell culture, BioReagent

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
12352207
PubChem物質ID:
NACRES:
NA.76

product name

泰乐菌素 溶液, 8 mg/mL in 0.9% NaCl, 0.1 μm filtered, BioReagent, suitable for cell culture

品質等級

無菌

0.1 μm filtered

產品線

BioReagent

形狀

solution

濃度

8 mg/mL in 0.9% NaCl

技術

cell culture | mammalian: suitable

雜質

endotoxin, tested

顏色

colorless to yellow

抗生素活性譜

Gram-positive bacteria
mycoplasma

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(C)=C\[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC

InChI

1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14+,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1

InChI 密鑰

ICVKYYINQHWDLM-KBEWXLTPSA-N

相關類別

一般說明

Chemical structure: macrolide
Tylosin is a macrolide antibiotic, which comprises of a 16-member lactone ring. This solution is recommended for use at 1 mL/L.

應用

Tylosin solution has been used as an antimicrobial agent in antibiotic susceptibility minimal inhibitory concentration(MIC) of E. coli and S. aureus isolates. It has also been used as a component of Dulbecco′s modified Eagle′s (DMEM) medium for self-inactivating lentivirus production and skin fibroblast cultivation.

生化/生理作用

Tylosin inhibits bacterial protein synthesis by binding to the large subunit 50S. It is effective against Gram-positive bacteria and mycoplasma and is used in veterinary medicine. It has been used to study implant site abscess prevention in cattle and Mycoplasma gallisepticum and Mycoplasma meleagridis infections.

包裝

20ML

準備報告

This product was formulated to contain 8 mg/ml tylosin in 0.9% sodium chloride.

儲存和穩定性

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and keep upright to prevent leakage.

其他說明

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Tools for characterizing bacterial protein synthesis inhibitors
Orelle C, et al.
Antimicrobial Agents and Chemotherapy, 57(12), 5994-6004 (2013)
Effects of a tylosin tartrate pellet added to cattle growth implants on the incidence of implant site abscesses
Zollers JrWG, et al.
The Protein Kinase Facts Book, 18(3), 258-261 (2002)
Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply
Szibor M, et al.
Test, 295(14), 4383-4397 (2020)
EVALUATION OF THE EFFECT OF TYLOSIN (MACROLIDE ANTIBIOTICS) ON MURINE TOXOPLASMOSIS
Asgari Q, et al.
International Journal of Pharmaceutical Sciences and Research, 9(7), 2891-2896 (2018)
Frizzled 1 and Wnt1 as new potential therapeutic targets in the traumatically injured spinal cord
Gonzalez P, et al.
Cellular and Molecular Life Sciences, 80, 1-32 (2020)

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