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T3205

Tamibarotene

Name: Tamibarotene
Brand: SIGMA

≥98% (HPLC)

同義詞:

-((5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl)benzoic acid, 4-(((5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino)carbonyl)-benzoic acid, AM 80, AM80, AMNOLAKE, Amnoid, N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl)-2-naphthyl)terephthalamic acid, N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)terephthalamic acid, NSC 608000, UNII-08V52GZ3H9

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About This Item

經驗公式（希爾表示法）:

C₂₂H₂₅NO₃

CAS號碼:

94497-51-5

分子量：:

351.44

MDL號碼:

MFCD00866188

分類程式碼代碼:

12352200

PubChem物質ID:

329826742

NACRES:

NA.77

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化驗

≥98% (HPLC)

形狀

powder

顏色

white to off-white

溶解度

DMSO: ≥10 mg/mL

儲存溫度

room temp

SMILES 字串

CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(cc3)C(O)=O)ccc12

InChI

1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)

InChI 密鑰

MUTNCGKQJGXKEM-UHFFFAOYSA-N

應用

Tamibarotene has been used to study its mode of action and therapeutic potential.[1]

生化／生理作用

Tamibarotene (Am80) is a RAR α agonist.

Tamibarotene (Am80) is a RAR α agonist. Tamibarotene was developed to overcome resistance to ATRA and is currently approved in Japan for treatment of recurrent acute promyelocytic leukemia (APL). The compound induces HL-60 cells differentiation and apoptosis. Similarly to TTNPB, the compound neither binds to nor transactivates the RXRs. In contrast to TTNPB (pan RAR agonist), Tamibarotene is rather specific toward RAR α. The compound is approximate 10 times more potent than ATRA.

Tamibarotene is a synthetic retinoid drug, highly stable and potent inducer of differentiation than ATRA (all-trans retinoic acid).[2] It showed mild growth inhibition in myeloma cells and HUVECs (human umbilical vein endothelial cell).[3]

特點和優勢

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

準備報告

Tamibarotene is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Synthetic retinoid Am80 results in improved exploratory and emotional behavior in the P8 substrain of senescence-accelerated mice.

Madoka Nakagomi et al.

Pharmacology, biochemistry, and behavior, 104, 1-9 (2013-01-22)

Am80 is a synthetic retinoid that has been used clinically for patients with acute promyelocytic leukemia and has been reported to affect the brain and its neurons. We investigated the influence of Am80 on anti-anxiety-like behavior, which is a characteristic

All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta.

Akira Uruno et al.

Journal of leukocyte biology, 90(2), 235-247 (2011-03-12)

ATRA and a synthetic RAR agonist tamibarotene (Am80) induce granulocytic differentiation of human acute leukemia HL-60 cells and have been used in antineoplastic therapy. ATRA induces CD38 antigen during HL-60 cell differentiation, which interacts with CD31 antigen on the vascular

Am80, a retinoic acid receptor agonist, ameliorates murine vasculitis through the suppression of neutrophil migration and activation.

Chie Miyabe et al.

Arthritis and rheumatism, 65(2), 503-512 (2012-12-04)

Vasculitis is characterized by leukocyte infiltration in the vessel walls, with destructive damage to mural structures. Retinoids are compounds that bind to retinoic acid receptors and exert biologic activities similar to those of vitamin A, including modulatory effects on cell

Successful treatment of relapsed and refractory extramedullary acute promyelocytic leukemia with tamibarotene.

Harris V Naina et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(18), e534-e536 (2011-04-13)

Oral administration of retinoic acid receptor-alpha/beta-specific ligand Am80 suppresses experimental autoimmune uveoretinitis.

Hiroshi Keino et al.

Investigative ophthalmology & visual science, 52(3), 1548-1556 (2010-09-24)

To determine whether synthetic retinoic acid receptor (RAR)-α/β-specific agonist Am80 reduces inflammation in experimental autoimmune uveoretinitis (EAU). Naive CD4(+) T cells were activated with anti-CD3, anti-CD28, and transforming growth factor (TGF)-β, in the presence or absence of Am80. Intracellular expression

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重要文件

Tamibarotene

≥98% (HPLC)

About This Item

推薦產品

屬性

化驗

形狀

顏色

溶解度

儲存溫度

SMILES 字串

InChI

InChI 密鑰

描述

應用

生化／生理作用

特點和優勢

準備報告

安全資訊

儲存類別代碼

水污染物質分類（WGK）

閃點（°F）

閃點（°C）

文件

分析證明 (COA)

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