推薦產品
生物源
human
重組細胞
expressed in HEK 293 cells
化驗
>90% (SDS-PAGE)
形狀
liquid
分子量
~150 kDa by SDS-PAGE
包裝
pkg of 10 μg
儲存條件
avoid repeated freeze/thaw cycles
濃度
≥0.2 mg/mL
技術
ligand binding assay: suitable
雜質
<0.1 EU/μg endotoxin, tested
適合性
suitable for molecular biology
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... JAG1(182)
一般說明
Jagged-1是多个Notch受体的配体，并参与Notch信号的介导。它参与造血过程中的细胞命运决定。参与哺乳动物心血管发育的早期和晚期。抑制成肌细胞分化。增强成纤维细胞生长因子诱导的血管生成（体外）。Jagged-1中的缺陷是1型Alagille综合征（ALGS1）和法洛四联症（TOF）的原因。
由基因JAG1编码的Jagged-1是在脊椎动物中发现的锯齿状同源物。它由原始和成熟的人类造血细胞表达。编码的蛋白质包含EGF（表皮生长因子）重复序列，跨膜结构域和介于两者之间的富含半胱氨酸的区域。[1]
應用
生化／生理作用
外觀
溶于PBS中。
其他說明
信号肽和人Jagged-1（HJ1；CD339）（aa 1-1067）的胞外域在C末端与人IgG1的Fc部分融合。
儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells.
Katoh M and Katoh M
International Journal of Molecular Medicine, 17, 681-685 (2006)
B Varnum-Finney et al.
Blood, 91(11), 4084-4091 (1998-05-30)
We examined the expression of two members of the Notch family, Notch-1 and Notch-2, and one Notch ligand, Jagged-1, in hematopoietic cells. Both Notch-1 and Notch-2 were detected in murine marrow precursors (Lin-Sca-1+c-kit+). The Notch ligand, Jagged-1, was not detected
Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation.
Purow BW
Cancer Research, 65, 2353-2363 (2005)
The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells.
Karanu FN
The Journal of Experimental Medicine, 192, 1365-1372 (2000)
Hui Yang et al.
Biochemical pharmacology, 108, 47-57 (2016-03-27)
AMP-activated protein kinase (AMPK) signaling pathway plays a pivotal role in intracellular adaptation to energy stress during myocardial ischemia. Notch1 signaling in the adult myocardium is also activated in response to ischemic stress. However, the relationship between Notch1 and AMPK
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