SRP6552

TGF-β3 来源于小鼠

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• 同義詞: Transforming growth factor beta-3
• 分類程式碼代碼: 12352202
• NACRES: NA.32

屬性

• 生物源: mouse
• 重組細胞: expressed in E. coli
• 化驗: ≥98% (SDS-PAGE)
• 形狀: liquid
• 分子量: 25.5 kDa
• 包裝: pkg of 5 μg; pkg of 50 μg; pkg of 500 μg
• 濃度: 0.25 mg/mL
• 雜質: ≤1 EU/μg endotoxin (LAL test)
• UniProt登錄號: P04202
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: mouse ... TGF-beta-1(21803)

描述

一般說明

TGFβ3 (transforming growth factor β3) is one of the three isoforms of mammalian TGFβ, and all the isoforms share high sequence similarity at the active domains, with TGFβ3 showing highest similarity with TGFβ1.
Recombinant mouse TGF-β3 is a non-glycosylated, disulfide-linked homodimer, containing two 112 amino acid chains, with a total molecular weight of 25.5kDa.

The TGFB1 gene is mapped to human chromosome 19q13.2. The encoded protein is an anti-inflammatory cytokine.

生化／生理作用

TGFβ3 (transforming growth factor β3) shows higher expression levels during late stage tumors, and hence, is thought to be associated with tumorigenesis. However, studies also show that in skin, breast, oral and gastric mucosa and other types of tissue, this protein confers protection against tumorigenesis. It plays crucial role in the development of systems such as heart, breast and lung. It is essential for mouse embryonic palate fusion, as inactivation results in non-fusion of palatal shelves. This protein plays a crucial role in orofacial development and is essential for excisional wound repair in vivo.

外觀

0.25 mg/mL solution containing 20% ethanol and 0.12% acetic acid (AcOH) .

安全資訊

• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: does not flash
• 閃點（°C）: does not flash