SRP6185

Factor Va from human plasma

≥95% (SDS-PAGE)

• 同義詞: Activated protein C cofactor, Proaccelerin (labile factor)
• 分類程式碼代碼: 12352202
• NACRES: NA.32

屬性

• 生物源: human plasma
• 化驗: ≥95% (SDS-PAGE)
• 形狀: liquid
• 分子量: heavy chain 94.0 kDa; light chain 74 kDa
• 包裝: pkg of 10 μg
• UniProt登錄號: P12259
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... F5(2153)

描述

一般說明

Factor Va is a cofactor for the serine protease factor Xa, and in the presence of calcium ions they collectively assemble on a phospholipid surface to form the prothrombinase complex. The prothrombinase complex is responsible for the rapid conversion of prothrombin to thrombin. Factor Va is derived from the pro-cofactor, factor V, upon limited proteolysis by α-thrombin. The thrombin cleavage of factor V liberates two heavily glycosylated activation peptides from the central portion of the molecule which have no cofactor function. Factor Va is comprised of an NH2-terminal derived heavy chain (Mr=94,000) and a COOH-terminal derived light chain (Mr=74,000) which remain associated in the presence of calcium ions. The cofactor binds to phospholipid (cell membrane) surfaces and effectively serves as a receptor for membrane bound factor Xa. Complete assembly of the prothrombinase complex (factor Xa, factor Va, phospholipid, and calcium) results in a 300,000-fold increase in the rate of prothrombin conversion relative to the rate observed with factor Xa alone. The interaction between factor Va and factor Xa is mediated by both the heavy and light chain of factor Va, while the binding of prothrombin to factor Va is mediated solely by the heavy chain.

外觀

liquid in 41.3 μl 20 mM HEPES, 150 mM NaC1, pH 7.5, 5 mM CaCl2 +50% glycerol.

安全資訊

• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable