推薦產品
相關類別
一般說明
The gene EPO (erythropoietin) is mapped to human chromosome 7q22.[1] It is a glycoprotein hormone. EPO is generated in fetal liver and adult kidney. However, it can also be secreted by other organs, such as the heart, brain and lungs.[2] EPO is a member of the EPO/TPO (thrombopoietin) family and is found in the plasma.[3]
應用
- EPO (erythropoietin) has been used as a component of the culture medium for cardiac stem cells.[4]
- In cultured cerebellar granule cells and hippocampal neurons, it has been used to study effect of EPO on glutamate release.[5]
- It has also been used as a component of endothelial differentiation medium.[6]
生化／生理作用
EPO (erythropoietin) regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis.[3] It interacts with EPO receptor and is responsible for the cellular responses. EPO is expressed in many cancers, including breast cancer, renal cancer, gastric cancer, hepatocellular carcinoma and central nervous system tumors. In addition, it is a hypoxia responsive cytokine and a pro-angiogenic factor.[2] This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.[7] It can protect from brain damages due to ischemia and enhances memory as well as cognitive ability in humans suffering from vascular dementia.[7]
外觀
Lyophilized from a PBS solution.
準備報告
Centrifuge the vial prior to opening.
重構
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
從最近期的版本中選擇一個：
客戶也查看了
Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics.
Fang B, et al.
Blood, 105, 2733-2740 (2005)
Beth J Allison et al.
Journal of applied physiology (Bethesda, Md. : 1985), 126(1), 44-50 (2018-11-02)
Erythropoietin (EPO) is being trialled in preterm infants to reduce brain injury, but high doses increase lung injury in ventilated preterm lambs. We aimed to determine whether early administration of lower doses of EPO could reduce ventilation-induced lung injury and
Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia.
Kawakami M, et al.
The Journal of Biological Chemistry, 276, 39469-39475 (2001)
Micro and nano-scale in vitro 3D culture system for cardiac stem cells.
Hosseinkhani H, et al.
Journal of Biomedical Materials Research Part A, 94, 1-8 (2010)
PlanHab: Hypoxia counteracts the erythropoietin suppression, but seems to exaggerate the plasma volume reduction induced by 3 weeks of bed rest.
Keramidas ME, et al.
Physiological Reports, 4, e12760-e12760 (2016)
Active Filters
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務
