SRP2091

FGF-1 human

recombinant, expressed in insect cells, ≥85% (SDS-PAGE)

• 同義詞: AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-alpha, FGFA, GLIO703, HBGF1
• 分類程式碼代碼: 12352202
• NACRES: NA.26

屬性

• 生物源: human
• 重組細胞: expressed in insect cells
• 化驗: ≥85% (SDS-PAGE)
• 形狀: frozen liquid
• 分子量: ~19.2 kDa
• 包裝: pkg of 5 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 濃度: 500 μg/mL
• 顏色: colorless to clear
• NCBI登錄號: NM_000800
• UniProt登錄號: P05230
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... FGF1(2246)

描述

一般說明

The gene FGF1 (fibroblast growth factor 1) encodes a member of the fibroblast growth factor (FGF) family. It encodes a pro-angiogenic protein that is ubiquitously expressed and is secreted via transmembrane translocation from the cells through a nonclassical secretory pathway in response to stress. It has the ability to permeate membranes composed of acidic phospholipids.[1]

應用

FGF-1 (fibroblast growth factor 1) has been used as a growth factor to study the effect of FGF1 on early branching events in isolated endoderm obtained from embryonic mouse lung.[2] It has also been used to study the neuroprotection effect of FGF1 on cerebellar granule neurons obtained from rats.[3]

生化／生理作用

Acidic fibroblast growth factor (FGF-1) and basic fibroblast growth factor (FGF-2) are ubiquitous cytokines found in many tissues. They have effects on multiple cell types derived from mesoderm and neuroectoderm, including endothelial cells. FGF proteins are small peptides of 155 to 268 amino acid residues. The degree of sequence identity between different family members is 30-60 % in a "central domain" of approx. 120 amino acids. This domain confers to FGFs a common tertiary structure and the ability to bind to heparin. Secreted FGFs signal to target cells by binding and activating cell-surface tyrosine kinase FGF receptors (FGFRs; 6, 7). The function of FGFs and FGFRs during embryonic development and adult physiology has been addressed by gain- and loss-of-function experiments in several animal model organisms. These studies have shown that FGFs act as key regulators of developmental events.

The protein fibroblast growth factor 1, functions intracellularly to protect cells against stress.[4] The protein functions as an angiogenic factor that participates in tissue repair, carcinogenesis, and maintenance of vasculature stability. Its expression is found to be upregulated in in patients with rheumatic arthritis.[5] It serves as a prognostic biomarker in several cancers and a potential therapeutic target for patients with non-small cell lung cancer.[6]

外觀

Clear and colorless frozen liquid solution

準備報告

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable