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Merck
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SML3600

Sigma-Aldrich

AZ10606120 dihydrochloride

≥98% (HPLC)

同義詞:

2-(1-Adamantyl)-N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)quinolin-5-yl]acetamide dihydrochloride, AZ 10606120 dihydrochloride, AZ-10606120 dihydrochloride, Compound-17 dihydrochloride, N-[2-({2-[(2-Hydroxyethyl)amino]ethyl}amino)-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidee dihydrochloride

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About This Item

經驗公式(希爾表示法):
C25H34N4O2·2HCl
CAS號碼:
分子量::
495.48
分類程式碼代碼:
51111800
分類程式碼代碼:
12352200
NACRES:
NA.04

品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated
protect from light
under inert gas

顏色

white to beige

溶解度

H2O: 2 mg/mL, clear (Warmed)

儲存溫度

room temp

SMILES 字串

O=C(NC1=CC=CC2=C1C=CC(NCCNCCO)=N2)CC3(C[C@H]4C5)C[C@@H](C4)C[C@@H]5C3.[2HCl]

生化/生理作用

AZ-10606120 is a potent purinoceptor P2X7 negative allosteric modulator that antagonizes ATP-dependent P2X7 activation (IC50 against ATP-induced ethidium bromide uptake = 2.3 nM and 24 nM, respectively, using human or rat P2X7 HEK293 transfectants; [ATP] = EC50) in a non-competitive and slowly reversible manner via affinity interaction at an allosteric pocket (human/rat P2X7 KD = 1.4 nM/19 nM) distinct from the KN-62- or ATP-binding site. A useful tool for probing P2X7-mediated physiological and pathological processes both in cultures (0.1-10 µM) and in vivo (e.g. 5 mg/kg i.p., 300 nM i.m., or 3 µg i.c.v.; in mice).

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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