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Merck
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文件

I1149

Sigma-Aldrich

碘乙酰胺

BioUltra

同義詞:

2-Iodoacetamide, Monoiodoacetamide, alpha-Iodoacetamide

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About This Item

線性公式:
ICH2CONH2
CAS號碼:
144-48-9
分子量：:
184.96
Beilstein:
1739080
EC號碼:
205-630-1
MDL號碼:
MFCD00008028
分類程式碼代碼:
12352202
PubChem物質ID:
24278486
NACRES:
NA.77

生物源

synthetic (organic)

產品線

BioUltra

化驗

≥99% (NMR)

形狀

powder

雜質

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

mp

92-95 °C (lit.)

溶解度

H2O: 0.5 M, clear, colorless

負離子痕跡

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

正離子痕跡

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

儲存溫度

2-8°C

SMILES 字串

NC(=O)CI

InChI

1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)

InChI 密鑰

PGLTVOMIXTUURA-UHFFFAOYSA-N

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相關類別

應用

碘乙酰胺已用于：
  • 蛋白质组学分析的蛋白质消化
  • 烷基化蛋白质样品
  • 牛奶过敏原、β-乳球蛋白（BLG）和α-乳清蛋白（ALA）的变性

生化／生理作用

碘乙酰胺（IAA）被用于抑制糖酵解，因为它能够不可逆地抑制糖酵解酶甘油醛-3-磷酸脱氢酶（GAPDH）。IAA用于研究半胱氨酸残基在酶催化和脑细胞转运过程中的作用。它可以与巯基乙醇和谷胱甘肽等低分子量硫醇化合物发生反应。IAN还可能阻断菠萝蛋白酶、组织蛋白酶C、梭状芽孢蛋白酶和羧肽酶P等酶。
碘乙酰胺在肽测序中胱氨酸残基的烷基化试剂。它是活性位点上含有胱氨酸的酶的的一种不可逆抑制剂。它与组氨酸残基的反应速度要慢得多，但这种活性是核糖核酸酶抑制的原因。

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Aquatic Chronic 4 - Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析證明 (COA)

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