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Merck
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重要文件

SML3028

Sigma-Aldrich

Apostatin-1

≥98% (HPLC)

同義詞:

N-Cycloheptyl-?-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]-benzeneacetamide

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About This Item

經驗公式(希爾表示法):
C19H27N3OS
CAS號碼:
分子量::
345.50
分類程式碼代碼:
12352200
NACRES:
NA.77
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品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O=C(C(C1=CC=CC=C1)SC2=NCCN2C)NC3CCCCCC3

InChI 密鑰

OXBMBNASDMMXSA-UHFFFAOYSA-N

生化/生理作用

Apostatin-1 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. Apostatin-1 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently Apostatin-1 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.
cell penetrant apoptosis inhibitor that activates autophagy that potently and selectively inhibits TRADD

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Daichao Xu et al.
Nature, 587(7832), 133-138 (2020-09-25)
Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If cell death is prevented without restoring cellular homeostasis, it may lead to a persistent dysfunctional and pathological state. Although mechanisms of cell death have been thoroughly

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