SML2944
Mca-YVADAPK(Dnp)-OH trifluoroacetate
≥97% (HPLC)
同義詞:
Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp), TFA salt, Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, TFA salt, Mca-YVADAPK(Dnp), TFA salt (Mca = 7-Methoxycoumarin-4-yl; Dnp = 2,4-dinitrophenyl)
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About This Item
經驗公式（希爾表示法）:
C53H64N10O19 · xC2HF3O2
分子量：:
1145.13 (free base basis)
分類程式碼代碼:
12352200
NACRES:
NA.77
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生化／生理作用
Mca-YVADAPK(Dnp)-OH is a widely used fluorescent substrate for caspase-1 (ICE cleaves between D & A) and angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm).
Popular fluorescent substrate for caspase-1 (ICE) and angiotensin-converting enzyme 2 (ACE2).
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
從最近期的版本中選擇一個：
ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats.
Erin B Bruce et al.
Experimental gerontology, 111, 133-140 (2018-07-15)
The obesity epidemic is multi-generational and is particularly debilitating in the aging population, necessitating the use of pharmaceutical interventions. Recent evidence suggests that increasing the activity of the angiotensin converting enzyme-2 [ACE2]/angiotensin-(1-7)[Ang-(1-7)]/Mas receptor (MasR) axis in obese animal models leads
Jiantao Song et al.
Bioscience reports, 40(6) (2020-05-29)
Angiotensin-converting enzyme 2 (ACE2) is considered as an endogenous negative regulator of renin-angiotensin system (RAS), exerting multiple cardiovascular protective roles. Whether mechanical stretch modulates ACE2 expression remains unknown. The present study aimed at investigating whether ACE2 is involved in physiological
Chad Vickers et al.
The Journal of biological chemistry, 277(17), 14838-14843 (2002-01-30)
Human angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a zinc metalloprotease whose closest homolog is angiotensin I-converting enzyme. To begin to elucidate the physiological role of ACE2, ACE2 was purified, and its catalytic activity was characterized. ACE2 proteolytic activity has a pH
M Enari et al.
Nature, 380(6576), 723-726 (1996-04-25)
Binding of Fas ligand or an agonistic anti-Fas antibody induces apoptosis in Fas-bearing cells. The interleukin-1Beta-converting enzyme (ICE) is a cysteine protease that is involved in apoptosis induced by various stimuli, including Fas-mediated apoptosis. Several ICE homologues have been identified
Chhinder P Sodhi et al.
Journal of immunology (Baltimore, Md. : 1950), 203(11), 3000-3012 (2019-10-28)
Angiotensin-converting enzyme 2 (ACE2) is a potent negative regulator capable of restraining overactivation of the renin-angiotensin system, which contributes to exuberant inflammation after bacterial infection. However, the mechanism through which ACE2 modulates this inflammatory response is not well understood. Accumulating
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