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Merck
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重要文件

SML2571

Sigma-Aldrich

CPHPC

≥98% (HPLC)

同義詞:

(2′R)-Adipoyldi-D-proline, (R)-1-[6-[(R)-2-Carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl-]pyrrolidine-2-carboxylic acid, 1,1′-(1,6-Dioxo-1,6-hexanediyl)bis[D-proline], GSK 2315698, GSK-2315698, GSK2315698, Miridesap, R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl]pyrrolidine-2-carboxylic acid, Ro 63-8695, Ro-63-8695

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About This Item

經驗公式(希爾表示法):
C16H24N2O6
CAS號碼:
分子量::
340.37
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77
暫時無法取得訂價和供貨情況

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

N2([C@H](CCC2)C(=O)O)C(=O)CCCCC(=O)N1[C@H](CCC1)C(=O)O

InChI

1S/C16H24N2O6/c19-13(17-9-3-5-11(17)15(21)22)7-1-2-8-14(20)18-10-4-6-12(18)16(23)24/h11-12H,1-10H2,(H,21,22)(H,23,24)/t11-,12-/m1/s1

InChI 密鑰

HZLAWYIBLZNRFZ-VXGBXAGGSA-N

生化/生理作用

CPHPC (Miridesap; Ro 63-8695) is an orally active serum amyloid P (SAP) blocker that targets the ligand-binding site on the SAP planar binding (B) face with each of its two D-proline moieties (up to two SAP per CPHPC), being able to crosslink and dimerize two SAP pentamers to form B face-to-B face decamers. CPHPC potently inhibits SAP binding to amyloid fibrils in vitro (IC50 = 0.9 μM using AD Aβ amyloid fibrils) and exhibits in vivo efficacy toward liver & circulating SAP clearance as well as SAP removal from tissue amyloid deposits (1-5 mg/mL in drinking water; human SAP transgenic mice).
Serum amyloid P (SAP) blocker that inhibits SAP binding to amyloid fibrils, clears circulating SAP and removes SAP from tissue amyloid deposits in vivo.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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