The density is not reported for this compound. The molecular weight is 260.33. The solubility is tested at 2mg/mL in DMSO, however other sources suggest that it is soluble in DMSO up to 10mg/mL. This rate has not been validated.
推薦產品
產品名稱
辛-(R)-2HG, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
film
儲存條件
desiccated
顏色
colorless
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
O[C@H](CCC(=O)O)C(=O)OCCCCCCCC
InChI 密鑰
UJZOKTKSGUOCCM-LLVKDONJSA-N
應用
生化／生理作用
抑制 α-酮戊二酸/α-KG 依赖性双加氧酶类的肿瘤代谢产物 D-2-羟基戊二酸的膜渗透前体形式。
辛基-(R)-2HG (Octyl-D-2HG) 是肿瘤细胞因 NADP + 依赖性异柠檬酸脱氢酶基因 IDH1 和 IDH2 突变而产生的肿瘤代谢产物 D-2-羟基戊二酸盐 (D-2HG) 的膜渗透前体形式。D-2HG 通过与 α-KG 结合竞争抑制多种 α-酮戊二酸/α-KG-依赖性双加氧酶。通过 Octyl-(R)-2HG 处理 (1-50 mM) 的细胞 D-2HG 传递显示出抑制脱甲基酶活性（~148%H3K9me2 和 ~310%H3K79me2 上调；U-87 mg 中 50 mm）以及因为分别抑制 α-KG-依赖性双加氧酶脯氨酰羟化酶 (PHD) 和胶原脯氨酰-4-羟化酶 (C-P4H)而增加 HIF-1α通过, 降低内皮抑素水平。
準備報告
The density is not reported for this compound. The molecular weight is 260.33. The solubility is tested at 2mg/mL in DMSO, however other sources suggest that it is soluble in DMSO up to 10mg/mL.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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What is the density of this product? I can´t find it and I want to have a 100mM stock.
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