推薦產品
形狀
powder
品質等級
儲存條件
protect from light
顏色
light yellow to dark yellow
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
CN(CC(O)=O)C1=S=[Mn-4]([C+]=O)([C+]=O)([C+]=O)([C+]=O)S1
生化／生理作用
CORM-401（Mn(CO)4(S2CNMe(CH2CO2H))）是一种可生成至少三摩尔当量CO的含锰一氧化碳释放分子（CORM）。由于CO的可逆性结合，CORM-401在溶液中相对稳定（在PBS中放置4小时后CO的损失为0.33 mol当量；时间零点的[CORM-401] =1 mM），而当存在CO受体或能组织CO重新集合的配体存在时会导致更多的CO释放（在44 μM的肌红蛋白存在下，在0.8分钟的t1/2时3.2 mol当量的CO被转移到了铁上；时间零点的[CORM-401] = 10 μM）。据报道，通过CORM-401实现的CO输入可解偶联线粒体呼吸且抑制人内皮细胞中的糖酵解（10-100 μM），并松弛与去氧肾上腺素预收缩的离体大鼠主动脉环（25 μM）。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Sian H Crook et al.
Dalton transactions (Cambridge, England : 2003), 40(16), 4230-4235 (2011-03-16)
[Mn(CO)(4){S(2)CNMe(CH(2)CO(2)H)}], 1, is shown to be a CO releasing molecule providing at least three moles CO per mole of compound. The mechanism of CO loss is dissociative and reversible and was investigated using Gaussian 09 calculations. The reversible binding of
Sarah Fayad-Kobeissi et al.
Biochemical pharmacology, 102, 64-77 (2016-01-02)
Carbon monoxide (CO) is generated by heme oxygenase-1 (HO-1) and displays important signaling, anti-apoptotic and anti-inflammatory activities, indicating that pharmacological agents mimicking its action may have therapeutic benefit. This study examined the biochemical and pharmacological properties of CORM-401, a recently
Patrycja Kaczara et al.
Biochimica et biophysica acta, 1847(10), 1297-1309 (2015-07-18)
Carbon monoxide (CO), a product of heme degradation by heme oxygenases, plays an important role in vascular homeostasis. Recent evidence indicates that mitochondria are among a number of molecular targets that mediate the cellular actions of CO. In the present
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