推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
CC1=CC(NC(N2CCN(CC3=CC=C(C(F)(F)F)C=C3)CC2)=S)=NC(C)=C1
InChI
1S/C20H23F3N4S/c1-14-11-15(2)24-18(12-14)25-19(28)27-9-7-26(8-10-27)13-16-3-5-17(6-4-16)20(21,22)23/h3-6,11-12H,7-10,13H2,1-2H3,(H,24,25,28)
InChI 密鑰
PJNSZIQUFLWRLH-UHFFFAOYSA-N
生化／生理作用
NCT-503是磷酸甘油酸脱氢酶（PHGDH）的抑制剂，可催化葡萄糖衍生的丝氨酸合成的第一步限速步骤。NCT-503可减少葡萄糖衍生的丝氨酸生成，并抑制培养物中PHGDH依赖性癌细胞和异种移植瘤的生长，并导致MDA-MB-468细胞发生G1/S细胞周期阻滞。NCT-503能够减少将葡萄糖和外源丝氨酸的一碳单元掺入核苷酸，这可能有助于其发挥抗癌活性。NCT-503对PHGDH的IC50 值为2.5 μM，对一组其他脱氢酶无效，并且在一组168个G蛋白偶联受体（GPCR）中具有极低的交叉反应性。NCT-503已被发现对3-PG和NAD+均不具有竞争性，并且表现出良好的稳定性（溶于测定缓冲液中48小时后，>98%）和水溶性。
推薦產品
NCT-503 阴性对照品，是NCT-503的结构类似物，可从Sigma购买。要了解更多信息并购买NCT-503阴性对照品， 请单击此处 。
訊號詞
Warning
危險聲明
危險分類
Skin Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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