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About This Item
經驗公式（希爾表示法）:
C13H10N2O
CAS號碼:
分子量：:
210.23
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 5 mg/mL, clear (warmed)
儲存溫度
2-8°C
SMILES 字串
O=C(C1=CC=NC=C1)/C=C/C2=CN=CC=C2
InChI
1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+
InChI 密鑰
UOWGYMNWMDNSTL-ONEGZZNKSA-N
應用
3PO已用作6-磷酸果糖-2-激酶/果糖-2，6-二磷酸酶3(PFKFB3)抑制剂，用于研究其对结直肠癌细胞中细胞活力丧失、凋亡和坏死性凋亡的影响。它还用作 PFKFB3 抑制剂来抑制糖酵解，并研究其对曲贝替定（TRB）和鲁比卡丁（LUR）处理的人巨噬细胞（hMF）中细胞活力和产生活性氧（ROS）的影响。
生化／生理作用
3PO 是一种有效的选择性 PFKFB3 抑制剂（6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶），PFKFB3 可降低糖酵解流量并抑制葡萄糖摄取。3PO 对转化细胞具有选择性抑制细胞生长的作用，并抑制荷瘤小鼠肿瘤的生长。
通过3PO介导的PFKFB3阻断对糖酵解的抑制减少了癌症和炎症的病理性血管生成。3PO有助于调节内皮细胞的增殖和迁移。它还减少了内皮细胞的促炎激活和 体内实验性炎症。因此，它可能是一种治疗慢性炎症的潜在疗法。其在人内皮细胞中的抗炎活性与其靶PFKFB3无关。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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