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Merck
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重要文件

SML0802

Sigma-Aldrich

ZLN005

≥95% (HPLC)

同義詞:

2-(4-tert-Butylphenyl)-1H-benzimidazole, 2-[4-(1,1-Dimethylethyl)phenyl]-1H-benzimidazole

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About This Item

經驗公式(希爾表示法):
C17H18N2
CAS號碼:
分子量::
250.34
分類程式碼代碼:
12352200
NACRES:
NA.77
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品質等級

化驗

≥95% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 10 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

[nH]1c2c(nc1c3ccc(cc3)C(C)(C)C)cccc2

InChI

1S/C17H18N2/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H,1-3H3,(H,18,19)

InChI 密鑰

LQUNNCQSFFKSSK-UHFFFAOYSA-N

生化/生理作用

ZLN005 is a transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). ZLN005 increased PGC-1 and downstream gene transcription in skeletal muscle, while reducing hepatic PGC-1α and gluconeogenesis genes. ZLN005 increased fat oxidation and improved the glucose tolerance, pyruvate tolerance, insulin sensitivity, hyperglycemia and dyslipidemia of diabetic db/db mice.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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Tianyu Hang et al.
International journal of molecular sciences, 24(10) (2023-05-27)
Type-2 diabetes (T2DM) and arterial hypertension (HTN) are major risk factors for heart failure. Importantly, these pathologies could induce synergetic alterations in the heart, and the discovery of key common molecular signaling may suggest new targets for therapy. Intraoperative cardiac

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