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Merck
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重要文件

SML0269

Sigma-Aldrich

尼替西农

≥95% (HPLC)

同義詞:

2-(2-硝基-4-三氟甲基苯甲酰基)-1,3-环己二酮, 2-[2-硝基-4-(三氟甲基)苯甲酰基] 环己烷-1,3-二酮, NTBC, SC 0735, 尼替松

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About This Item

經驗公式(希爾表示法):
C14H10F3NO5
CAS號碼:
分子量::
329.23
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

品質等級

化驗

≥95% (HPLC)

形狀

powder

顏色

white to brown

溶解度

DMSO: ≥5 mg/mL

儲存溫度

−20°C

SMILES 字串

[O-][N+](=O)c1cc(ccc1C(=O)C2C(=O)CCCC2=O)C(F)(F)F

InChI

1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2

InChI 密鑰

OUBCNLGXQFSTLU-UHFFFAOYSA-N

基因資訊

human ... HPD(3242)

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應用

尼替西农已经被用于:
  • 诱导肝损伤 [1]
  • 治疗 肩突硬蜱 细胞,抑制羟苯丙酮酸双加氧酶[2]
  • 在补充水中的活性以阻止有毒代谢产物在人肝细胞移植小鼠中的蓄积,[3]
  • 以研究其对细菌性脓疱素产生的影响。[4]

生化/生理作用

尼替西农是4-羟苯基丙酮酸氧化酶(双加氧酶)的竞争性和可逆抑制剂。
尼替西农是一种竞品抑制剂,可逆地抑制4-羟苯基丙酮酸氧化酶(双加氧酶)。尼替西农用于治疗1型遗传性酪氨酸血症,可阻止酪氨酸降解为有害物质。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Eva Thimm et al.
Molecular genetics and metabolism, 102(2), 122-125 (2010-11-30)
Psychomotor impairment has been described in hypertyrosinemia types II and III (HT III). Only recently cognitive deficits have also been reported in hypertyrosinemia type I (HT I). The pathogenic mechanisms responsible are unknown. Since implementation of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC, Nitisinone (Swedish
Saikat Santra et al.
Expert opinion on pharmacotherapy, 9(7), 1229-1236 (2008-04-22)
Hereditary tyrosinaemia type 1 is a rare inherited metabolic condition, which leads to a fatal multisystemic disease in childhood. Since 1992, nitisinone - a compound developed from work on triketone herbicides - has become an effective pharmacological treatment by inhibiting
Immunization with AgTRIO, a protein in Anopheles saliva, contributes to protection against Plasmodium infection in mice
Dragovic SM, et al.
Cell host & microbe, 23(4), 523-535 (2018)
Jean Larochelle et al.
Molecular genetics and metabolism, 107(1-2), 49-54 (2012-08-14)
Hepatorenal tyrosinemia (HT1, fumarylacetoacetate hydrolase deficiency, MIM 276700) can cause severe hepatic, renal and peripheral nerve damage. In Québec, HT1 is frequent and neonatal HT1 screening is practiced. Nitisinone (NTBC, Orfadin ®) inhibits tyrosine degradation prior to the formation of
Andrew J Preston et al.
Annals of the rheumatic diseases, 73(1), 284-289 (2013-03-21)
Alkaptonuria (AKU) is a rare metabolic disease caused by deficiency of homogentisate 1,2 dioxygenase, an enzyme involved in tyrosine catabolism, resulting in increased circulating homogentisic acid (HGA). Over time HGA is progressively deposited as a polymer (termed ochronotic pigment) in

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