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SML0136

Sigma-Aldrich

TGN-020

≥98% (HPLC)

同義詞:

2-（烟酰胺）-1,3,4-噻二唑, N-（1,3,4-噻二唑-2-基）-3-吡啶甲酰胺, N-（1,3,4-噻二唑-2-基）吡啶-3-甲酰胺, N-（1,3,4-噻二唑）-间-烟酰胺

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About This Item

經驗公式（希爾表示法）:
C8H6N4OS
CAS號碼:
51987-99-6
分子量：:
206.22
MDL號碼:
MFCD00708771
分類程式碼代碼:
12352200
PubChem物質ID:
329825185
NACRES:
NA.77
暫時無法取得訂價和供貨情況

化驗

≥98% (HPLC)

形狀

powder

顏色

white to tan

溶解度

DMSO: ≥8 mg/mL

儲存溫度

room temp

SMILES 字串

O=C(Nc1nncs1)c2cccnc2

InChI

1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13)

InChI 密鑰

AGEGZHOPKZFKBP-UHFFFAOYSA-N

應用

人肺上皮细胞Beas2B经TGN-020处理以研究其他对香烟烟雾提取物诱导的CCN1分泌的影响。[1]

生化／生理作用

TGN-020是大脑中丰度最高的水通道——水通道蛋白4（AQP4）的抑制剂。水通道蛋白（AQP）是维持流体稳态并使水穿过屏障膜所需的水通道，但它可促进病理性细胞体积变化并引起损伤状态下的水肿。在局灶性脑缺血小鼠模型中，AQP4抑制剂TGN-020的预处理可显著降低与缺血性损伤相关的脑水肿的体积。
水通道蛋白4（AQP4）抑制剂

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000405923
0000405922
0000397847
0000405923
0000405922

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Hyung-Geun Moon et al.
PloS one, 8(7), e68199-e68199 (2013-07-23)
Inflammation involves in many cigarette smoke (CS) related diseases including the chronic obstructive pulmonary disease (COPD). Lung epithelial cell released IL-8 plays a crucial role in CS induced lung inflammation. CS and cigarette smoke extracts (CSE) both induce IL-8 secretion
Hiromu Monai et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(22), 11010-11019 (2019-05-18)
Spontaneous waves of cortical spreading depolarization (CSD) are induced in the setting of acute focal ischemia. CSD is linked to a sharp increase of extracellular K+ that induces a long-lasting suppression of neural activity. Furthermore, CSD induces secondary irreversible damage
Jian Li et al.
Brain research bulletin, 170, 162-173 (2021-02-17)
The extracellular signal-regulated kinase (ERK) pathway has been reported to play a pivotal role in mediating spinal cord injury (SCI) progression. The present study aimed to investigate the effects of phosphorylated ERK1/2 (p-ERK1/2) inhibition on SCI-induced astrocyte activation and inflammation
Dervis Dasdelen et al.
Mini reviews in medicinal chemistry, 20(6), 498-512 (2019-10-28)
In the literature screening, aquaporins were found in the cerebral structures including the pia mater, choroid plexus, ependyma, piriform cortex, hippocampus, dorsal thalamus, supraoptic and suprachiasmatic nuclei, white matter and subcortical organ. Among these, the most common are AQP1, AQP4
Yuji Suzuki et al.
Neurosurgery, 82(6), 842-846 (2017-06-25)
Aquaporin (AQP) water channels play a significant role in mesenchymal microvascular proliferation and infiltrative growth. AQPs are highly expressed in malignant astrocytomas, and a positive correlation is observed between their expression levels and histological tumor grade. To examine the utility
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Questions

  1. We purchased a quantity of TGN-020 earlier this year but have had exceptional difficulty finding an effective solvent for this compound (tried DCM and H2O). Does Sigma-Aldrich have data on compatible solvents? Primary lit hasn't been helpful. Thanks!

    1 answer

    1. The solubility specification for this product is >/= 8mg/mL in DMSO. The rate may be higher and is lot-specific, however, the minimum concentration in DMSO is 8 mg/mL. A brief literature search shows that HCl, Ethanol, and Dimethylformamide have also been used to dissolve this compound.
      Please see the sample Certificate of Analysis for example:
      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/SML0136-5MG0000258843.pdf

      If solubility issues continue, we kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, and click on "Report Product Issues" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.

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