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SMB00515

Sigma-Aldrich

Afzelin

≥90% (LC/MS-UV)

同義詞:

3,4′,5,7-四羟基黄酮 3-鼠李糖甙, Afzeloside, 山柰酚, 山柰酚3-O-α-L-鼠李糖甙, 山柰酚3-鼠李糖甙

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About This Item

經驗公式（希爾表示法）:
C21H20O10
CAS號碼:
482-39-3
分子量：:
432.38
MDL號碼:
MFCD00210589
分類程式碼代碼:
12352205
PubChem物質ID:
329825042
NACRES:
NA.25
暫時無法取得訂價和供貨情況

化驗

≥90% (LC/MS-UV)

形狀

solid

溶解度

DMSO: 1 mg/mL

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

−20°C

SMILES 字串

OC1=CC(O)=C(C(C(O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)=C(C3=CC=C(O)C=C3)O4)=O)C4=C1

InChI

1S/C21H20O10/c1-8-15(25)17(27)18(28)21(29-8)31-20-16(26)14-12(24)6-11(23)7-13(14)30-19(20)9-2-4-10(22)5-3-9/h2-8,15,17-18,21-25,27-28H,1H3/t8-,15-,17+,18+,21-/m0/s1

InChI 密鑰

SOSLMHZOJATCCP-AEIZVZFYSA-N

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相關類別

一般說明

Afzelin来源于植物的天然产物。黄酮类醇苷Afzelin的主要来源为掌叶榕和香睡莲。[1]

應用

保护DNA、抗氧化、抗炎、吸收紫外线和抗菌活性。Afzelin已用于高效液相色谱法(HPLC)分析，以检测复方蒿提取物中的主要成分。[2]

生化／生理作用

Afzelin是NOS抑制剂和NADPH氧化酶抑制剂，具有抗菌、抗炎、抗凋亡和抗肿瘤活性。Afzelin可作为铜绿假单胞菌相关疾病的有效治疗药物。[3]Afzelin还能促进乳腺癌细胞凋亡，抑制细胞增殖。在小鼠模型中表现出抗哮喘作用。[1]

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
122228350V
AD122228251V
122228251V

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Seoung Woo Shin et al.
PloS one, 8(4), e61971-e61971 (2013-04-30)
Ultraviolet (UV) radiation induces DNA damage, oxidative stress, and inflammatory processes in human keratinocytes, resulting in skin inflammation, photoaging, and photocarcinogenesis. Adequate protection of skin against the harmful effects of UV irradiation is essential. Therefore, in this study, we investigated
Afzelin attenuates asthma phenotypes by downregulation of GATA3 in a murine model of asthma
Zhou Wenbo and Nie Xiuhong
Molecular Medicine Reports, 12(1) (2015)
Sang Yeol Lee et al.
Molecules (Basel, Switzerland), 19(3), 3173-3180 (2014-03-20)
The crude ethyl acetate extract of the leaves of Cornus macrophylla showed antibacterial activity against Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals. Bioactivity-guided separation led to the isolation of kaempferol 3-O-α-L-rhamnopyranoside (afzelin). The structure was determined based
Agrimoniin, an active ellagitannin from Comarum palustre herb with anti-α-glucosidase and antidiabetic potential in streptozotocin-induced diabetic rats
Kashchenko N, et al.
Molecules (Basel), 22(1), 73-73 (2017)
Parham Taslimi
Journal of biochemical and molecular toxicology, 34(11), e22566-e22566 (2020-07-03)
Tyrosinase enzyme is a functional oxidase that is extensively divided in nature. It is the main enzyme in melanin synthesis and is also involved in designating the color of mammalian hair and skin. Additionally, it is accountable for the unfavorable

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