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重要文件

SCP0041

Sigma-Aldrich

[Ala28]-淀粉样蛋白β 25-35

≥95% (HPLC)

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About This Item

經驗公式（希爾表示法）:
C42H74N12O14S1
CAS號碼:
173993-86-7
分子量：:
1003.17
分類程式碼代碼:
12352209
NACRES:
NA.32
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化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥68%

儲存條件

protect from light

UniProt登錄號

P05067

儲存溫度

−20°C

基因資訊

human ... APP(351)

Amino Acid Sequence

Gly-Ser-Asn-Ala-Gly-Ala-Ile-Ile-Gly-Leu-Met

一般說明

β-淀粉样肽是阿尔茨海默病大脑老年斑特征的主要成分。 Aβ（25-35）代表在阿尔茨海默′病斑块形成期间聚集的区域，并且是涉及神经营养和神经毒性作用的功能域。该序列中的替换有助于理解与膜插入、聚集和原纤维形成相关的结构特征以及随后的神经毒性作用。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number
BB1138

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Hui-Hsu Gavin Tsai et al.
Proteins, 78(8), 1909-1925 (2010-03-17)
The mechanisms of interfacial folding and membrane insertion of the Alzheimer's amyloid-beta fragment Abeta(25-35) and its less toxic mutant, N27A-Abeta(25-35) and more toxic mutant, M35A-Abeta(25-35), are investigated using replica-exchange molecular dynamics in an implicit water-membrane environment. This study simulates the

Questions

1–2 of 2 Questions  

  1. How should the [Ala28]-Amyloid β 25-35 product, SCP0041 (CAS 173993-86-7), be dissolved or reconstituted?

    1 answer

    1. Solubility testing for this product has not been conducted. However, information from other competitors/vendors available online indicates the following solubility levels: 0.5 mg/mL in water and 2.5 mg/mL in 10% DMSO.

      Helpful?

  2. What is the solubility of the product for making stock solution. Is it soluble in water or not. Product name : [Ala28]- Amyloid beta 25-35, Catalogue no- SCP004, Quantity-5mg

    1 answer

    1. The solubility of this product is not determined. However, similar Amyloid β 25-35 products are soluble at 1 mg/ml in 1% acetic acid. In addition, various sources report that this material may be solubilized in the following:
      0.5 mg/mL in water
      2.5 mg/mL in 10% DMSO

      Helpful?

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