跳轉至內容
Merck
全部照片(1)

文件

SCP0038

Sigma-Aldrich

β 淀粉样蛋白 1-42 大鼠

≥90% (HPLC)

同義詞:

β-Amyloid 1-42, Amyloid for Rat, Rat Amyloid β 1-42

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C199H307N53O59S1
分子量::
4417.95
分類程式碼代碼:
12352200
NACRES:
NA.32

化驗

≥90% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥75%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

一般說明

淀粉样蛋白 β (Aβ) 1-42 是在阿尔茨海默病(AD)中出现的淀粉样斑块的主要成分。它具有交叉的β结构和平行的β片层

應用

大鼠淀粉样蛋白 β 1-42已被用作脑室内(ICV)注射/海马内灌注的淀粉样蛋白β (Aβ)寡聚糖,用于建立大鼠阿尔茨海默病(AD)模型。

生化/生理作用

与Aβ(1–40)相比,淀粉样蛋白 β 1-42更容易在体外形成淀粉样纤维丝。Aβ1-42注射液可导致脑功能失调,出现学习和记忆缺损。淀粉样蛋白β(Aβ)是指衍生自淀粉样前体蛋白的肽,其长度在37–43个氨基酸之间变化。Aβ(s)肽,其肽片段和突变片段用于研究广泛的代谢和调节功能,包括激酶的激活、胆固醇转运的调节、作为转录因子的功能和炎症的调节因子。Aβ(s)肽及其肽片段还用于研究氧化应激、金属结合和蛋白质交联机制,例如阿尔茨海默病和神经变性。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Jing Wang et al.
Molecular medicine reports, 23(6) (2021-04-22)
Ginkgolide B (GB), the diterpenoid lactone compound isolated from the extracts of Ginkgo biloba leaves, significantly improves cognitive impairment, but its potential pharmacological effect on astrocytes induced by β‑amyloid (Aβ)1‑42 remains to be elucidated. The present study aimed to investigate the
Enes Akyuz et al.
Biomedicines, 8(3) (2020-03-19)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a complex etiology and characterized by cognitive deficits and memory loss. The pathogenesis of AD is not yet completely elucidated, and no curative treatment is currently available. Inwardly rectifying potassium (Kir)
Volodymyr A Yavorsky et al.
Frontiers in cellular neuroscience, 17, 1132092-1132092 (2023-05-01)
One of the signs of Alzheimer's disease (AD) is the formation of β-amyloid plaques, which ultimately lead to the dysfunction of neurons with subsequent neurodegeneration. Although extensive researches have been conducted on the effects of different amyloid conformations such as
Raheleh Farahzadi et al.
ACS chemical neuroscience, 11(10), 1424-1435 (2020-04-21)
Mesenchymal stem cells (MSCs) are of particular interest because of their potential in regenerative medicine. Stem cell-based therapies cast a new hope for neurodegenerative disease treatment as a regeneration strategy, including treatment for Alzheimer's disease (AD). A multitude of cytokines
Ruo-Meng Li et al.
Neural regeneration research, 18(6), 1347-1353 (2022-12-02)
Previous studies have shown that fibroblast growth factor 13 is downregulated in the brain of both Alzheimer's disease mouse models and patients, and that it plays a vital role in the learning and memory. However, the underlying mechanisms of fibroblast

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務