生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 61 kDa
物種活性
mouse, human, rat
濃度
~1 mg/mL
技術
ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... WASF1(8936)
一般說明
Wiskott–aldrich syndrome protein family member 1 (WAVE1) is encoded by the gene mapped to human chromosome 6q21-22. It is primarily expressed in brain and is characterized with a tripartite VCA (verprolin homology, cofilin homology and acidic) domain.
免疫原
The antiserum was produced against synthesized peptide derived from human WAVE1.
Immunogen Range: 91-140
Immunogen Range: 91-140
應用
Anti-WAVE1 antibody produced in rabbit has been used in immunoblotting.[1]
生化／生理作用
Members of WASP-family verprolin-homologous protein (WAVE) family plays a vital role in actin polymerisation and cytoskeletal organisation, which are essential for various cellular processes, including cell shape changes, cytokinesis, cell motility and membrane traffic. WAVE1 regulates chemoresistance during autophagy. The encoded protein plays an essential role in oligodendrocyte morphogenesis and myelination. In addition, it is also implicated in regulation of spine morphogenesis. Overexpression of the gene leads to the development of prostate cancer.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology.
Kim Y, et al.
Nature, 442(7104), 814-814 (2006)
Expression of the WASP verprolin-homologues (WAVE members) in human breast cancer.
Fernando H S, et al.
Oncology, 73(5-6), 376-383 (2007)
Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.
Suetsugu S, et al.
Biochemical and Biophysical Research Communications, 260(1), 296-302 (1999)
Knockdown of WAVE1 enhances apoptosis of leukemia cells by downregulating autophagy.
Zhang Z, et al.
International Journal of Oncology, 48(6), 2647-2656 (2016)
WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.
Kim H J, et al.
The Journal of Neuroscience, 26(21), 5849-5859 (2006)
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