SAB4200565
Monoclonal Anti-ZFP36/TTP antibody produced in mouse
clone TTP6, tissue culture supernatant
同義詞:
Anti-G0/G1 switch regulatory protein 24, Anti-G0S24, Anti-Growth factor-inducible nuclear protein NUP475, Anti-NUP475, Anti-RNF162A, Anti-TIS11, Anti-TIS11A, Anti-Zinc finger protein 36 homolog, Anti-tristetraprolin, Anti-zinc finger protein 36, C3H type, homolog (mouse), Anti-zinc finger protein, C3H type, 36 homolog (mouse)
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About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
暫時無法取得訂價和供貨情況
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生物源
mouse
品質等級
共軛
unconjugated
抗體表格
tissue culture supernatant
抗體產品種類
primary antibodies
無性繁殖
TTP6, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~45 kDa
物種活性
mouse, bovine, rat, dog, human, monkey
技術
western blot: 1:4,000-1:8,000 using extracts of HepG2 cells.
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... ZFP36(7538)
一般說明
Monoclonal Anti-ZFP36/TTP (mouse IgM isotype) is derived from the hybridoma TTP6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide corresponding to an internal sequence of human ZFP36/TTP, conjugated keyhole limpet hemocyanin (KLH). ZFP36 (also known as tristetraprolin or TTP) is a RNA-binding protein. It belongs to the RNA-binding zinc-finger protein family. TTP consists of a cysteine-cysteine-cysteine-histidine (CCCH) zinc finger motif and uridine-rich elements (AREs) in the 3′ untranslated region (3′ UTR) of target mRNA. This gene is located on human chromosome 19q13.1.
免疫原
a peptide corresponding to an internal sequence of human ZFP36/TTP conjugated KLH.
應用
Monoclonal Anti-ZFP36/TTP antibody has been used in immunoblotting.
生化／生理作用
ZFP36 (also known as tristetraprolin or TTP) participates in controlling the expression of AU-rich element (ARE) -containing mRNAs. It participates in accelerating mRNA decay. ZFP36 was found to limit the expression of a number of critical genes frequently overexpressed in inflammation and cancer. It also plays a major role in differentiation, reprogramming, metabolism, proliferation, pluripotency, tumorigenesis and immunity.
外觀
Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
The RNA binding protein tristetraprolin down-regulates autophagy in lung adenocarcinoma cells
Dong F, et al.
Experimental Cell Research, 367(1), 89-96 (2018)
The role of RNA-binding protein tristetraprolin in cancer and immunity
Guo J, et al.
Medical Oncology (Northwood, London, England), 34(12), 196-196 (2017)
The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin
Wu X, et al.
PLoS Genetics, 14(5), e1007366-e1007366 (2018)
ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity
Moore MJ, et al.
eLife, 7, e33057-e33057 (2018)
Tristetraprolin: A novel target of diallyl disulfide that inhibits the progression of breast cancer
Xiong T, et al.
Oncology Letters, 15(5), 7817-7827 (2018)
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