推薦產品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~59 kDa
物種活性
human
加強驗證
independent
Learn more about Antibody Enhanced Validation
濃度
~1.0 mg/mL
技術
indirect immunofluorescence: 1.2-2.5 μg/mL using paraformaldehyde fixed HEK-293T cells
western blot (chemiluminescent): 0.5-1 μg/mL using lysates of HEK-293T cells
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PSPC1(55269)
相關類別
一般說明
Paraspeckle protein 1 (PSP1/ PSPC1) has two isoforms, α and β. PSPC1 belongs to the Drosophila melanogaster behavior, human splicing (DBHS) protein family.
應用
Anti-PSPC1 (N-terminal) antibody produced in rabbit may be used in several immunochemical techniques including immunoblotting (~59 kDa) and immunofluorescence. It has also been used in RNA immunoprecipitation (RIP) experiment.
生化／生理作用
Paraspeckle protein 1(PSP1/ PSPC1) is implicated in the regulation of nuclear receptors such as the progesterone receptor and the thyroid receptor, and in a wide range of processes such as transcription, splicing, and RNA metabolism. It acts as a marker for paraspeckles, which are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei that are often located adjacent to splicing speckles.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Circadian RNA expression elicited by 3?-UTR IRAlu-paraspeckle associated elements
Torres M, et al.
eLife, 5(9), e14837-e14837 (2016)
The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold
Knott GJ, et al.
Nucleic Acids Research, 44(9), 3989-4004 (2016)
Manon Torres et al.
eLife, 5 (2016-07-22)
Paraspeckles are nuclear bodies form around the long non-coding RNA, Neat1, and RNA-binding proteins. While their role is not fully understood, they are believed to control gene expression at a post-transcriptional level by means of the nuclear retention of mRNA
P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner
Fox AH, et al.
Molecular Biology of the Cell, 16(11), 5304-5315 (2005)
Pei Wen Lee et al.
The Journal of biological chemistry, 298(11), 102563-102563 (2022-10-10)
RNA-binding proteins of the DBHS (Drosophila Behavior Human Splicing) family, NONO, SFPQ, and PSPC1 have numerous roles in genome stability and transcriptional and posttranscriptional regulation. Critical to DBHS activity is their recruitment to distinct subnuclear locations, for example, paraspeckle condensates
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