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文件

S7796

Sigma-Aldrich

紫苏雷素 硫酸盐

≥580 μg/mg (USP)

同義詞:

O-3-Deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->4)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1->6))-2-deoxy-L-streptamine sulfate (2:5) (salt)

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About This Item

經驗公式（希爾表示法）:
C19H37N5O7 · 2.5H2O4S
CAS號碼:
53179-09-2
分子量：:
692.72
EC號碼:
258-414-4
分類程式碼代碼:
51281665
PubChem物質ID:
329824589
NACRES:
NA.85

形狀

powder

濃度

≥580 μg/mg (USP)

顏色

white to off-white

抗生素活性譜

Gram-negative bacteria

作用方式

protein synthesis | interferes

儲存溫度

−20°C

SMILES 字串

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3OC(CN)=CC[C@H]3N)[C@@H]2O.CN[C@@H]4[C@@H](O)[C@H](OC[C@]4(C)O)O[C@H]5[C@H](N)C[C@H](N)[C@@H](O[C@H]6OC(CN)=CC[C@H]6N)[C@@H]5O

InChI

1S/2C19H37N5O7.5H2O4S/c2*1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;5*1-5(2,3)4/h2*3,9-18,24-27H,4-7,20-23H2,1-2H3;5*(H2,1,2,3,4)/t2*9-,10+,11-,12+,13-,14-,15+,16-,17-,18-,19+;;;;;/m11...../s1

InChI 密鑰

CIKNYWFPGZCHDL-ZHFUJENKSA-N

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一般說明

Chemical structure: aminoglycoside

應用

Sisomicin is an aminoglycoside antibiotic isolated from Micromonopora inyoensis. It is effective against most strains of Klebsiellk spp., Escherichia coli, P. aeruginosa, Enterobacter and Proteus spp.. It is a potential treatment for conjunctiva . It is used in disk and tube dilution sensitivity test.

生化／生理作用

Sisomicin interferes with protein synthesis at the level of functional ribosome assembly. The mechanism is similar to that of gentamycin. Sisomicin closely resembles gentamicin but is more effective against Pseudomonas aeruginosa and indole-positive Proteus.

包裝

250MG,1G,5G

儲存和穩定性

Keep container tightly closed in a dry and well-ventilated place.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險聲明

H312 + H332,H360

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

分析證明 (COA)

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D M Livermore et al.
The Journal of antimicrobial chemotherapy, 66(1), 48-53 (2010-11-17)
the emergence of carbapenemases in Enterobacteriaceae is driving a search for therapeutic alternatives. We tested ACHN-490, a sisomicin derivative that evades all plasmid-mediated aminoglycoside-modifying enzymes, against 82 carbapenem-resistant Enterobacteriaceae isolates. Comparators included internationally and locally available aminoglycosides. Methods The isolates
Bo Li et al.
Rapid communications in mass spectrometry : RCM, 22(22), 3455-3471 (2008-10-15)
The characterization of unknown impurities present in netilmicin and sisomicin by liquid chromatography (LC) coupled with mass spectrometry (MS) is described. The volatile ion-pairing agent trifluoroacetic acid (TFA) was used for the retention of the main compounds and their impurities
Irene Galani et al.
Journal of chemotherapy (Florence, Italy), 24(4), 191-194 (2012-10-09)
The in vitro activity of plazomicin was evaluated against 300 multidrug resistant (MDR) (carbapenemase and/or ESBL-producing) isolates from four hospitals in Athens, an area where carbapenemase-producing organisms are endemic. Most of the isolates were also resistant to the legacy aminoglycosides
Robert T Cass et al.
Antimicrobial agents and chemotherapy, 55(12), 5874-5880 (2011-09-14)
ACHN-490 is an aminoglycoside with activity against multidrug-resistant pathogens, including those resistant to currently used aminoglycosides. Two randomized, double-blind, placebo-controlled clinical studies investigated the pharmacokinetics (PK), safety, and tolerability of ACHN-490 injection in healthy subjects. Study 1 used a parallel-group
Stephen Hanessian et al.
Chemical communications (Cambridge, England), 46(12), 2013-2015 (2010-03-12)
Aminoglycoside 66-40C, an unprecedented 16-membered bis-azadiene macrocyclic natural product isolated from the Micromonospora producer of the antibiotic sisomicin, was synthesized following a biomimetic strategy which definitively established its origin as arising from a remarkably selective non-enzymatic macro-dimerization.
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