S6324
Monoclonal Anti-SNX6 antibody produced in mouse
clone SNX6-76, ascites fluid, buffered aqueous solution
同義詞:
Anti-MSTP010, Anti-Sorting Nexin 6, Anti-TFAF2, Anti-Tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2
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About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
暫時無法取得訂價和供貨情況
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生物源
mouse
品質等級
共軛
unconjugated
抗體表格
ascites fluid
抗體產品種類
primary antibodies
無性繁殖
SNX6-76, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~47 kDa
物種活性
mouse, human, bovine, rat
包裝
antibody small pack of 25 μL
技術
indirect ELISA: suitable
western blot: 1:2,500-1:5,000 using total extracts of A549 cells
同型
IgA
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... SNX6(58533)
mouse ... Snx6(72183)
rat ... Snx6(362738)
相關類別
一般說明
Monoclonal Anti-SNX6 (mouse IgA isotype) is derived from the hybridoma SNX6-76 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.
SNX6 (sorting nexin 6) is a BACE1 (Β-site APP cleaving enzyme-1)-associated protein and a constituent of retromer. It belongs to the sorting nexin (SNX) family that has a PX (Phox homology) domain at its amino terminus and a BAR (Bin/amphiphysin/Rvc) domain at its carboxyl region. It is located on chromosome 14q13.
應用
Monoclonal Anti-SNX6 antibody produced in mouse has been used in immunoblotting and ELISA.
生化／生理作用
SNX6 (sorting nexin 6) helps in retrograde trafficking of the cation-independent mannose-6-phosphate receptor (CI-MPR) and sortilin. Interaction of SNX6 with breast cancer metastasis suppressor-1 induces transcriptional repression. It helps in the synthesis of lamin A and its transportation to the nuclear envelope .
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes
Kamnasaran D, et al.
Genomics, 85(5), 608-621 (2005)
Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope
Gonzalez-Granado JM, et al.
PLoS ONE, 9(12) (2014)
Akshay Bareja et al.
The Journal of biological chemistry, 293(17), 6449-6459 (2018-03-14)
The insulin-like growth factor 1 receptor (IGF1R) is a receptor tyrosine kinase with critical roles in various biological processes. Recent results from clinical trials targeting IGF1R indicate that IGF1R signaling pathways are more complex than previously thought. Moreover, it has
Ana Jimenez-Orgaz et al.
The EMBO journal, 37(2), 235-254 (2017-11-22)
Retromer is an endosomal multi-protein complex that organizes the endocytic recycling of a vast range of integral membrane proteins. Here, we establish an additional retromer function in controlling the activity and localization of the late endosomal small GTPase RAB7. Surprisingly
The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway
Bareja A, et al.
Test, 293(17), 6449-6459 (2018)
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